Bupropion, originally named Amfebutamone, sold under the brand name Wellbutrin, is a medication commonly prescribed for the treatment of major depressive disorder (MDD), as is often used off-label for attention deficit hyperactivity disorder (ADHD), anxiety, obesity, and bipolar disorder. While it has demonstrated efficacy in addressing certain mental health issues, it is essential to examine the potential harms associated with its use, particularly considering its modulation of neurotransmitters like norepinephrine (NE) and dopamine. This article aims to shed light on the risks of Wellbutrin use, with a focus on its implications for pregnant or lactating women. Additionally, we'll explore the idea that the indications for Wellbutrin may stem from underlying nutrition and lifestyle factors rather than a deficiency of the medication.

As of 2021, Bupropion, maintained its position as the 18th most prescribed drug in the United States. With an estimated 29,099,445 prescriptions filled, it remains a widely utilized medication in the realm of psychiatric pharmaceuticals. This notable figure underscores the prevalence of its use in addressing various conditions, including depression and smoking cessation.

The estimated number of patients in the United States receiving Bupropion in 2021 reached 6,412,363. This statistic reflects the significant impact and reach of Bupropion across diverse patient populations. Its popularity could be attributed to its purported effectiveness in managing depressive disorders, ADHD, anxiety, and aiding individuals in smoking cessation efforts.

Wellbutrin functions by influencing the levels of neurotransmitters in the brain, primarily inhibiting the breakdown of norepinephrine and dopamine. While this mechanism contributes to its antidepressant effects, it also raises concerns about potential side effects and risks. Altering neurotransmitter levels can lead to a range of adverse effects, with the most common including:

• anxiety
• dry mouth
• hyperventilation
• irregular heartbeats
• irritability
• restlessness
• shaking
• trouble sleeping

Here are some of the possible harms and common side effects associated with Wellbutrin:

1. Insomnia: Difficulty sleeping is a frequently reported side effect.
2. Dry Mouth: Many users experience a persistent dry mouth.
3. Headache: Headaches are a common complaint.
4. Nausea and Vomiting: Some people may feel nauseous or vomit.
5. Constipation: Gastrointestinal issues, such as constipation, are possible.
6. Dizziness: Users may experience dizziness or lightheadedness.
7. Weight Loss: Appetite suppression can lead to weight loss.
8. Increased Sweating: Excessive sweating is another potential side effect.

Serious Side Effects

1. Seizures: Wellbutrin can increase the risk of seizures, especially at higher doses.
2. Hypertension: Elevated blood pressure has been reported.
3. Mania: In some cases, Wellbutrin can trigger manic episodes in individuals with bipolar disorder.
4. Psychiatric Symptoms: Agitation, anxiety, and psychosis have been observed.
5. Liver Damage: Although rare, Wellbutrin can cause liver injury.

Allergic Reactions

1. Rash and Itching: Skin reactions such as rashes and itching can occur.
2. Swelling: Swelling of the face, lips, tongue, or throat can indicate a severe allergic reaction.
3. Difficulty Breathing: Respiratory issues are a severe sign of an allergic reaction.

Cardiovascular Effects

1. Palpitations: Users may experience an irregular heartbeat or palpitations.
2. Increased Heart Rate: Tachycardia, or an increased heart rate, can occur.

Psychiatric Risks

1. Suicidal Thoughts and Behaviors: Like other antidepressants, Wellbutrin carries a risk of increased suicidal thoughts and behaviors, especially in young adults and adolescents.

Other Considerations

1. Drug Interactions: Wellbutrin can interact with other medications, leading to adverse effects or reduced efficacy.
2. Use in Pregnancy and Breastfeeding: See Below. The safety of Wellbutrin during pregnancy and breastfeeding is not well established and should be discussed with a healthcare provider.

Long-Term Risks

1. Dependence and Withdrawal: Although less common, some users may develop dependence or experience withdrawal symptoms upon discontinuation.

While the approach of inhibiting the reuptake of dopamine and norepinephrine aims to enhance the availability of these neurotransmitters in the brain, an imbalance can lead to adverse effects. Excessive levels or prolonged elevated concentrations of these neurotransmitters may contribute to overstimulation and disrupt normal neural signaling.

Norepinephrine is a neurotransmitter involved in the body's "fight or flight" response, influencing heart rate and blood pressure. Medications that impact norepinephrine reuptake can lead to cardiovascular side effects, including increased heart rate and elevated blood pressure. Individuals with pre-existing cardiovascular conditions may be at a higher risk for complications.

Altered levels of dopamine and norepinephrine can influence mood and behavior. In some cases, inhibiting reuptake may contribute to psychiatric symptoms such as anxiety, restlessness, or irritability. Balancing the desired therapeutic effects with potential adverse psychological consequences is a delicate consideration.

Abruptly discontinuing medications that inhibit dopamine and norepinephrine reuptake can lead to withdrawal symptoms. These symptoms may include mood swings, fatigue, and cognitive disturbances. Additionally, some individuals may develop a dependence on these medications, requiring careful management to taper off gradually.

Dopamine and norepinephrine play roles in regulating sleep and appetite. Disrupting these neurotransmitters can lead to sleep disturbances, insomnia, or changes in appetite. Monitoring and addressing these side effects are crucial for maintaining overall well-being during the course of treatment.

The response to medications that inhibit dopamine and norepinephrine reuptake can vary widely among individuals. Factors such as genetic predispositions, existing medical conditions, and concurrent medications may influence how the body reacts to these interventions. Individualized treatment plans and close monitoring are essential components of responsible prescribing.​

Pregnancy and lactation introduce unique considerations when it comes to medication use. The use of Wellbutrin (bupropion) or any other medication during pregnancy requires careful consideration of potential risks and benefits. While studies on the safety of Wellbutrin during pregnancy are inconclusive, there is evidence suggesting a potential association with adverse outcomes, including preterm birth and low birth weight. Additionally, Wellbutrin and its metabolites are present in human breast milk excretions, raising concerns about its impact on nursing infants including alterations in neurotransmitters. Expectant or breastfeeding mothers should engage in thorough discussions with their healthcare providers to weigh the potential benefits against the risks and explore alternative treatment options.

Here are some considerations regarding the potential harms of taking Wellbutrin during pregnancy:

1. Risk of Birth Defects: Researchers have observed ​a potential association between the use of certain antidepressants, including Wellbutrin, during the first trimester of pregnancy and a slightly increased risk of certain birth defects. However, the absolute risk is generally low. In rabbits, increased incidences of fetal malformations and skeletal variations were observed at the lowest dose tested (25 mg per kg per day, approximately equal to the maximum recommended human dose on a mg per m2 basis) and greater. 
2. Neonatal Complications: Neonatal complications, such as withdrawal symptoms or adaptation issues, have been reported in infants born to mothers who took Wellbutrin during pregnancy. These symptoms are typically transient and managed by healthcare professionals.
3. Preterm Birth and Low Birth Weight: Researchers have observed a possible association between antidepressant use during pregnancy and an increased risk of preterm birth or low birth weight. In rabbits, decreased fetal weights were observed at 50 mg per kg and greater. However, the overall impact is modest, and the reasons for these associations are complex.
4. Persistent Pulmonary Hypertension of the Newborn (PPHN): There have been concerns about a potential link between maternal antidepressant use, including Wellbutrin, and an increased risk of PPHN. However, research results have been inconsistent, and the absolute risk remains low.

Wellbutrin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It's essential for individuals taking Wellbutrin and considering pregnancy, or those who become pregnant while on the medication, to discuss their situation with healthcare professionals. Abruptly stopping antidepressant medication can lead to a recurrence of depressive symptoms, which may have its own set of risks during pregnancy.

Healthcare providers will carefully weigh the potential risks and benefits based on the individual's mental health needs. In some cases, healthcare professionals may recommend continuing the medication, adjusting the dosage, or exploring alternative treatments.

Pregnant individuals should inform their healthcare providers about their medication use and work collaboratively to make informed decisions that prioritize both maternal mental health and the well-being of the developing fetus.

While the active ingredient in Wellbutrin plays a significant role in its pharmacological effects, it's important not to overlook the inactive ingredients in the formulation. While they make up a smaller portion of the overall product, their cumulative impact should not be underestimated, especially considering the frequent administration of the medication.

Though often considered inert, inactive ingredients can still interact with the body in various ways, potentially influencing drug absorption, metabolism, and overall therapeutic efficacy. Moreover, individual sensitivities or allergic reactions to certain inactive ingredients can occur, further emphasizing the importance of evaluating the entire list of components.
​
Even seemingly minor alterations in inactive ingredients can have profound implications, particularly when considering long-term usage. Over time, repeated exposure to these substances may contribute to cumulative effects or unexpected reactions. Therefore, comprehensive scrutiny of all ingredients, active and inactive alike, is essential for a thorough assessment of the safety profile of Wellbutrin and other pharmaceutical products.

The vibrant hues that adorn our favorite processed foods often come from artificial food colorings, but behind the visual appeal lies a potential risk, particularly for pregnant or lactating women. Artificial food color usually contains petroleum and is manufactured in a chemical process that includes formaldehyde, aniline, hydroxides, and sulfuric acids. Most impurities in the food color are in the form of salts or acids. Sometimes lead, arsenic, and mercury may be present as impurities. The U.S. FDA is yet to study the effects of synthetic dyes on behavior in children. 

To date, there are numerous scientific articles highlighting the relationship of consumption of food colorings to the following health conditions:

• Attention Deficit Hyperactivity Disorder
• Attention Deficit Disorder with Hyperactivity
• Hyperkinetic Syndrome
• Anaphylaxis
• Chemically-Induced Liver Damage
• Food Allergies
• Leukocytoclastic Vasculitis
• DNA damage
• Oxidative Stress
• Asthma
• Allergies
• Angioedema
• Excitotoxicity
• Neurodevelopmental Disorders
• Urticaria

Underlying these conditions are the documented mechanics of action that cause physiologic imbalance, which include:

• Cytotoxicity
• Hepatotoxicity
• Genotoxicity
• Mutagenicity
• Neurotoxicity

​Research has raised concerns about the consumption of food colorings and their potential adverse effects, including implications for conditions like ADHD, autism, and gastrointestinal dysfunction.

There is a substantial amount of data exploring the connection between artificial food colorings and ADHD. Researchers suggest that certain artificial colorings may exacerbate hyperactivity and inattention in children with ADHD. Pregnant women, mindful of their diet's impact on fetal development, may choose to limit the intake of foods containing these colorings.

The relationship between food colorings and autism spectrum disorders (and the underlying inflammation in the brain) is a topic of ongoing investigation. Meta-analysis have documented a link, emphasizing the need for caution, especially during pregnancy and lactation. As the developing brain is susceptible to external influences, limiting exposure to artificial additives becomes a consideration for expectant and nursing mothers.

Artificial food colorings have been associated with gastrointestinal disturbances, ranging from discomfort to more severe issues. Pregnant women, already navigating changes in digestion due to hormonal shifts, may choose to minimize exposure to food colorings to promote digestive well-being during this crucial period.

Potential Harms for Pregnant and Lactating Women:

1. Fetal Development: The developing fetus is particularly vulnerable to external influences. Limited research suggests that certain food colorings may cross the placental barrier, potentially impacting fetal development.
2. Breast Milk Composition: Lactating women should be mindful of their dietary choices, as food colorings have been detected in breast milk. While the significance of this transfer is still under investigation, cautious choices can contribute to ensuring the purity of breast milk.
3. Gastrointestinal Sensitivity: Pregnancy often brings about changes in digestion, and artificial food colorings may exacerbate gastrointestinal discomfort. Sensitivity to these additives varies, and pregnant women may choose to adopt a more natural and minimally processed diet.

For pregnant or lactating women concerned about the potential harms of food colorings, opting for a diet rich in whole, unprocessed foods becomes a valuable strategy. Choosing fruits, vegetables, and other naturally colorful sources can provide vibrant flavors without the need for artificial additives.

While the connection between food colorings and adverse health outcomes is an area of ongoing research, pregnant and lactating women may choose to err on the side of caution. Prioritizing a diet that minimizes artificial additives and focuses on nutrient-dense, whole foods is a proactive step toward supporting both maternal and fetal health. Always consult with healthcare professionals for personalized guidance based on individual circumstances and health considerations.

The concerns that arise with the safety of consuming PEG are multifold, including: 

1. Pollution: The process to produce polyethylene glycol requires a chemical reaction known as ethoxylation and the use of compounds known as ethylene oxide and 1,4-dioxane – two chemicals that have well-documented toxic effects on humans.
2. Contamination: PEGs are widely utilized for their ability to enhance penetration and absorption. But this also means that prolonged use or high doses of PEG can significantly enhance your body’s absorption of other toxins and harmful compounds that are found alongside PEGs or within the environment. 
3. Lack of studies: Because polyethylene glycol has numerous derivatives and molecular weights, extensive studies have only been conducted on a handful of different PEG compounds. There is limited information on the real impact of PEGs as a whole and more PEG toxicity research is needed to truly understand this compound’s effects on the human body.

Depending on manufacturing processes, PEGs may be contaminated with measurable amounts of ethylene oxide and 1,4-dioxane. The International Agency for Research on Cancer classifies ethylene oxide as a known human carcinogen and 1,4-dioxane as a possible human carcinogen. Ethylene oxide can also harm the nervous system and the California Environmental Protection Agency has classified it as a developmental toxicant based on evidence that it may interfere with human development. 

1,4-dioxane is also persistent. In other words, it doesn’t easily degrade and can remain in the environment long after it is rinsed down the shower drain. 1,4-dioxane can be removed from cosmetics during the manufacturing process by vacuum stripping, but there is no easy way for consumers to know whether products containing PEGs have undergone this process.In a study of personal care products marketed as “natural” or “organic” (uncertified), U.S. researchers found 1,4-dioxane as a contaminant in 46 of 100 products analyzed. 

While carcinogenic contaminants are the primary concern, PEG compounds themselves show some evidence of genotoxicity and if used on broken skin can cause irritation and systemic toxicity. PEG itself is classified as expected to be toxic or harmful as mentioned on the Environment Canada Domestic Substance List. The industry panel that reviews the safety of cosmetics ingredients concluded that some PEG compounds are not safe for use on damaged skin (although the assessment generally approved of the use of these chemicals in cosmetics). Also, PEG functions as a “penetration enhancer,” increasing the permeability of the skin to allow greater absorption of the ingredients — including harmful ingredients.

Researchers have observed that a large percentage of parents, caregivers, and practitioners described an explosion of neurological side effects seemingly correlated to polyethylene glycol administration. Those side effects include:

• Abnormal behavior
• Anger
• Anxiety 
• Mood swings
• Seizures
• Sensory disturbances

Commonly found in various products, such as medications, laxatives, and skincare items, PEG may lead to the following potential harms:

1. Gastrointestinal Issues: Oral ingestion of PEG, particularly in laxatives or medications, may cause gastrointestinal side effects such as bloating, cramps, gas, nausea, diarrhea, and vomiting.
2. Dehydration: Excessive use of PEG laxatives without adequate fluid intake can lead to dehydration. It's important to follow the recommended dosages and stay hydrated while using PEG-containing products.
3. Allergic Reactions: Although rare, some individuals may be allergic to PEG, leading to allergic reactions like rash, itching, swelling, or difficulty breathing. If any allergic symptoms occur, immediate medical attention is necessary.
4. Renal Impairment: PEG has been associated with cases of renal injury, particularly in individuals with pre-existing kidney conditions. People with kidney issues should use PEG-containing products cautiously under medical supervision.
5. Electrolyte Imbalance: Because of its ability to disrupt the flow of water, PEG laxatives can lead to electrolyte imbalances, which may result in abnormal levels of sodium, potassium, calcium, phosphate, and other electrolytes in the body. Severe electrolyte imbalances can have serious health consequences. Consumption of PEG has also been linked to an increased risk of metabolic acidosis, which is a build-up of acid and toxins in the body.
6. Systemic Absorption: While the systemic absorption of PEG from the gastrointestinal tract is generally low, excessive use or prolonged exposure may increase the risk of systemic absorption, potentially leading to adverse effects.
7. Hypersensitivity and Allergic Reactions: Individuals with a history of hypersensitivity to PEG or related compounds should avoid products containing PEG.  There are have been documented cases of an allergy to PEG. Some cases have even resulted in anaphylaxis – a severe and potentially life-threatening allergic reaction. Due to the risk of exposure to polyethylene glycol, the FDA has issued a warning to anyone with a known or suspected PEG allergy to communicate clearly with healthcare professionals as PEGs can be found lurking in medications, vaccines, contrast agents, and more. Researchers have estimated that approximately 72% of the US population has acquired anti PEG antibodies. The referenced study used blood samples taken from 1990-1999 and earlier, showing a steady increase over time in the percentage of those with antibodies to PEG, making it conservative to estimate, after two decades, that the incidence is closer to 80% today. 

People with pre-existing health conditions, especially those affecting the kidneys, should inform their healthcare providers before using PEG-containing products. As with any substance, individual responses to PEG can vary, and people experiencing adverse effects should seek medical attention promptly. It's important to weigh the risks and benefits of using PEG-based products based on individual health conditions and circumstances.

​Talc is a mineral commonly used in various products such as talcum powder, cosmetics, and personal care items. While talc is considered GRAS for external use, there have been concerns and controversies regarding potential health risks associated with its use, primarily when used in certain ways or in specific product formulations. Here are some of the concerns related to talc:

1. Contamination Concerns: Talc products have been found to be contaminated with substances like asbestos, which is a known carcinogen. While regulations and testing standards are in place to monitor and limit asbestos contamination in talc products, Johnson & Johnson, the maker of Johnson’s Baby Powder, is facing more than 9,000 plaintiffs in cases involving body powders with talc contaminated with asbestos.
2. Ovarian Cancer: There has been some controversy and litigation surrounding the potential link between talcum powder use in the genital area and an increased risk of ovarian cancer in women, due to contamination of asbestos. 
3. Respiratory Issues: Inhalation of talc powder (likely not a concern with the consumption of Wellbutrin), particularly in occupational settings such as talc mining or during certain industrial processes, may pose respiratory risks. Talc is closely related to asbestos, and in some natural deposits, talc may be contaminated with asbestos fibers, which are known respiratory hazards.
4. Pulmonary Effects in Infants: Although likely not a concern with the consumption of Wellbutrin, there have been reports of respiratory distress and other pulmonary issues in infants when talc-containing products, such as baby powders, are used excessively. Inhaling talc powder can be harmful to an infant's developing respiratory system.
5. Skin Irritation: Although likely not a concern with the consumption of Wellbutrin, in some individuals, talc may cause skin irritation or allergies. Redness, itching, or rash may occur, especially in people with sensitive skin.

Individuals concerned about the potential risks of talc-containing products should consider alternatives. As with any substance, moderation and careful use are advisable, and individuals experiencing adverse effects should seek medical advice.

​Titanium dioxide is a widely used pigment and additive in various products, including cosmetics, sunscreens, paints, and food items. While it is generally recognized as safe when used in approved applications, there are concerns about potential health risks associated with certain forms and uses of titanium dioxide. Here are some considerations:

1. Genotoxicity Concerns: Most relevant to the consumption of Wellbutrin, ome studies have suggested that certain forms of titanium dioxide nanoparticles may exhibit genotoxic effects, indicating potential damage to DNA. However, more research is needed to determine the relevance of these findings to human health and to establish safe exposure levels.
2. Potential for Nanoparticle Absorption: Titanium dioxide nanoparticles have raised concerns regarding their potential to penetrate the skin. While research is ongoing, the skin barrier generally prevents the absorption of larger particles. However, nanoparticles may raise questions about their long-term safety, and more studies are needed to understand their effects thoroughly.
   
3. Inhalation Risk (Unlikely a risk with Wellbutrin): Fine particles of titanium dioxide, particularly in the form of nanoparticles, can pose a respiratory risk when inhaled. Occupational exposure in industries such as manufacturing or handling titanium dioxide dust may be associated with respiratory irritation. However, consumer products like sunscreens or cosmetics typically use larger particles that are less likely to be inhaled.

It's important to note that regulatory agencies, such as the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA), have assessed the safety of titanium dioxide in approved uses. The permissible limits and specifications vary depending on the application.

Consumers concerned about titanium dioxide can choose products with alternatives or consult with healthcare professionals. As research continues, regulatory agencies may update guidelines to ensure the safe use of titanium dioxide in various products.

It's crucial to recognize that the conditions for which Wellbutrin is prescribed—ADHD, anxiety, obesity, and bipolar disorder—may not be caused by a deficiency of Wellbutrin itself. Rather, these conditions are complex and multifaceted, often influenced by underlying nutrition and lifestyle factors. Addressing these root causes is fundamental to comprehensive and sustainable mental health care.

Depression, a complex and pervasive mental health condition, often finds its roots in a myriad of factors, extending beyond the realm of neurochemistry to include nutrition and lifestyle elements. Understanding and addressing these underlying factors can play a pivotal role in comprehensive depression management. Here's a closer look at the nutrition and lifestyle aspects that contribute to this intricate mental health landscape:
1. Dietary Choices:

• Nutrient Deficiencies: Inadequate intake of essential nutrients, such as omega-3 fatty acids, vitamin D, B-vitamins, and minerals like zinc and magnesium, has been linked to an increased risk of depression. A diet rich in whole foods and diverse nutrients contributes to optimal brain function and mood regulation.

2. Gut-Brain Connection:

• Microbiome Health: The gut-brain axis underscores the bidirectional communication between the gut and the brain. An imbalance in gut microbiota, often stemming from poor dietary habits and antibiotic use, may contribute to inflammation and impact mental health. Probiotics and a fiber-rich diet can foster a healthy gut environment.

3. Blood Sugar Regulation:

• Stable Blood Sugar Levels: Fluctuations in blood sugar levels can affect mood and energy levels. Consuming a balanced diet with complex carbohydrates, fiber, and adequate protein helps regulate blood sugar and prevents energy crashes that may contribute to depressive symptoms.

4. Physical Activity:

• Exercise Benefits: Regular physical activity has been consistently associated with improved mood and reduced depressive symptoms. Exercise promotes the release of endorphins, neurotransmitters that act as natural mood lifters. Incorporating movement into daily routines is a valuable component of depression management.

5. Sleep Hygiene:

• Quality Sleep: Disrupted sleep patterns and insomnia are common features of depression. Prioritizing good sleep hygiene, including consistent sleep schedules, a comfortable sleep environment, and limiting screen time before bed, fosters better sleep quality and supports mental well-being.

6. Stress Management:

• Mind-Body Practices: Chronic stress is a significant contributor to depression. Mindfulness techniques, meditation, yoga, and other stress-reduction practices play a crucial role in managing and preventing depressive symptoms by promoting relaxation and emotional resilience.

7. Social Connections:

• Supportive Relationships: Social isolation and a lack of meaningful connections can contribute to depressive feelings. Nurturing positive relationships and maintaining a strong social support system are integral to emotional well-being.

Recognizing the impact of these nutrition and lifestyle factors on depression emphasizes the importance of a holistic approach to mental health. Integrating dietary changes, exercise, sleep hygiene, stress reduction, and social engagement into depression management plans provides individuals with a comprehensive toolkit for fostering mental well-being. As with any health concern, consultation with healthcare professionals is crucial to tailor interventions to individual needs and circumstances.

As with many psychotropic medications, Wellbutrin (bupropion) requires careful consideration when discontinuing to minimize the risk of withdrawal symptoms. Abruptly stopping Wellbutrin, also known as going "cold turkey," can lead to uncomfortable and potentially distressing withdrawal symptoms. It is crucial to approach the discontinuation of Wellbutrin with a gradual tapering process, personalized to individual needs, to ensure a smoother transition.

Withdrawal symptoms, often associated with sudden cessation of psychotropic drugs, can manifest as a range of physical and psychological discomforts. These may include dizziness, headaches, irritability, mood swings, insomnia, and flu-like symptoms. The severity and duration of withdrawal symptoms can vary from person to person.

To mitigate the risk of withdrawal symptoms, the American Psychiatric Association recommends a tapering approach for all antidepressants, including Wellbutrin. Tapering involves gradually reducing the dosage over a specified period, allowing the body to adjust to the decreasing levels of the medication.

It is paramount not to discontinue Wellbutrin without consulting your healthcare provider. Your doctor can create a personalized taper schedule based on factors such as the duration of your medication use, your current dosage, and any specific symptoms you may be experiencing. Tapering is typically done over 6 to 8 weeks to provide a gradual adjustment.

Every individual responds differently to medication changes. Your doctor can tailor the taper schedule to your unique needs, ensuring a careful balance between minimizing withdrawal symptoms and maintaining mental health stability.

If you begin to experience withdrawal symptoms during the tapering process, it is crucial to communicate promptly with your healthcare provider. They may need to reassess your taper schedule or make adjustments based on your symptoms. Restarting Wellbutrin can often alleviate withdrawal symptoms within a few days.

The journey of tapering off Wellbutrin is a collaborative effort between you and your healthcare provider. Open communication about your experiences and any emerging symptoms allows for adjustments that prioritize your well-being throughout the process.

In the realm of psychotropic medications, a thoughtful and gradual approach to discontinuation is key. Tapering off Wellbutrin under the guidance of your healthcare provider not only minimizes the risk of withdrawal symptoms but also ensures a smoother transition, prioritizing your mental health. Remember, your doctor is your ally in this process, and together, you can navigate the complexities of tapering to promote your overall well-being.

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​Spiller, Henry A., et al. “Bupropion Overdose: A 3-Year Multi-Center Retrospective Analysis.” The American Journal of Emergency Medicine, vol. 12, no. 1, Jan. 1994, pp. 43–45, https://doi.org/10.1016/0735-6757(94)90195-3. Accessed 28 Nov. 2021.

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Notice this "U" shape in the curve when examining the relationship between RT and morbidity and mortality. This curve suggests that some RT is clearly beneficial, but has the volume of RT increases past a certain point the benefits drop and it becomes harmful. The concept of a "biphasic response" is fundamental to understanding hormesis. It describes the characteristic dose-response relationship observed in hormetic processes, where a substance or stressor elicits opposite effects at low and high doses. The response can be visualized as a U-shaped or J-shaped curve, illustrating the beneficial effects at low doses and potential harm at higher doses. ​

Paluch, Amanda E, et al. “Resistance Exercise Training in Individuals with and without Cardiovascular Disease: 2023 Update: A Scientific Statement from the American Heart Association.” Circulation, 7 Dec. 2023, https://doi.org/10.1161/cir.0000000000001189. Accessed 11 Dec. 2023.

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Over the course of the past century, the Western culture has faced numerous health epidemics, from obesity to opioids. Today we are facing an epidemic of a different nature. The epidemic of loneliness.

We're more connected than ever, but are we feeling more alone? In the last 50 years, rates of loneliness have doubled in the United States. In a survey of over 20,000 American adults, it was found that almost half of respondents reported feeling alone, left out, and isolated. Further, one in four Americans shared that they rarely feel understood, and one in five people believe they rarely or never feel not close to people. Loneliness is on the rise for Americans regardless of geographic location, gender, race, or ethnicity.

Human beings did not evolve to be alone. Sociality plays a fundamental part in the wellbeing of Homo sapiens. Conversely, social isolation and loneliness are known risk factors for premature death, more so than being obese (Holt-Lunstad et al., 2015). Individuals who feel socially isolated and alone also have higher rates of cardiovascular disease, alcoholism and suicidality, physical diseases related to stress and compromised immune function, and in later life, greater risk of degenerative dementia. Even worse, researchers have observed that geriatric individuals who are considered lonely have a 45% increased risk of mortality (Leland, 2012; Perissinotto, Stijacic Cenzer and Covinsky, 2012). 

Moreover, lonely individuals experience reductions in reasoning and creativity. In addition to these reduced abilities, loneliness affects workplace productivity, as lonely individuals report less job satisfaction and are more likely to face unemployment. Not surprisingly, loneliness is commonly correlated with mental health concerns such as anxiety and depression. Similarly, loneliness is often associated with poor coping mechanisms, such as compulsive technology use, smoking, and self-harm. In other words, loneliness has both physical and psychological implications, many of which could be long term.

Before determining yourself as lonely, there is a difference between being alone and feeling lonely. Being alone and feeling lonely are not mutually dependent. Loneliness is a subjective experience, a feeling of sadness stemming from isolation or abandonment. But, a person can be alone without feeling lonely, since alone describes a state of being and lonely describes an emotional response to one's circumstance. For example, most people don't feel sad when they go to the restroom by themselves. A person can be alone in the sense that no other people are present, or alone in the sense that they are unaccompanied, even in a crowd.

When assessing loneliness, introverted and extroverted personalities should be taken into account, because some people enjoy the presence of being alone with themselves, whereas others are dependent on others to cope with not being by themselves. Being at either end of the spectrum, whether it is total isolation or complete dependence, is not considered a healthy behavioral pattern.

The predictors of loneliness is the basis for the identification of factors that cause and contribute to loneliness. The are three broad categories that influence the feeling of loneliness:

• problems with relationships;
• traumatic experiences;
• and, personal and developmental variables.

  
These categories may be subdivided into multiple factors that increase loneliness:

1. Personality: There are several personality factors that contribute to loneliness, including but not limited to, anxiety, an inability to assert oneself, and hyper-sensitivity. A victim mentality, a poor self concept, an external locus of control and shyness are other aspects of the personality that contribute to loneliness.
   
2. Affect: Loneliness is linked to negative affect and is typified in conditions such as depression, boredom, hopelessness, aggression, stress, anger, restlessness and tension.
3. Depression: A complicated vicious circle makes diagnosis tricky: people with poor social skills are more inclined to become depressed and yet depressed people are inclined to be lonely. There is a difference between depression and loneliness.
4. Problems in relationships: A lack of feelings of belonging, support and intimacy caused by poor communication promote loneliness. Social estrangement and separation and rejection also contribute to loneliness.
5. Marital status: Married people usually feel less lonely - but this is not the case when marriages are unfulfilling. Loneliness in marriage is linked to a lack of intimacy. Major changes that promote social isolation consist of events such as leaving home, a new career, separation from loved ones, breaking off a major relationship and moving house.
6. Illness or physical disability may lead to limited contact with other people.
7. Religious faith: Religions with strict behavioral prescriptions are likely to isolate individuals from free social interaction, potentially resulting in loneliness.
8. Academic achievement: Researchers have observed that students whose academic performance is poor are more likely to be lonely.
9. Leisure activities that alienate people from each other are watching television and surfing the Internet.

While it is impossible to avoid loneliness completely, it may be alleviated. It is recommended to investigate the contributory factors towards loneliness because knowledge of these may substantially lessen the impact of loneliness on people's mental health status. Such knowledge will contribute to an improved quality of life, productivity and health.

The "loneliness phenotype" can be triggered by sleep deprivation. Researchers have observed that a lack of sleep induces critical changes within the brain, altering behavior and emotions, while also disturbing essential metabolic processes and influencing the expression of immune-related genes. The end result is that people who are sleep-deprived avoid social interaction. This asocial profile is recognizable by other people, who, in turn, shun the sleep-deprived people in a psychosocial loop that perpetuates in a vicious cycle of loneliness and other mental health disorders.

Ali, S. (2018). What You Need to Know About the Loneliness Epidemic. [online] Psychology Today. Available at: https://www.psychologytoday.com/us/blog/modern-mentality/201807/what-you-need-know-about-the-loneliness-epidemic [Accessed 1 Sep. 2019].

Harris, R. (2015). Are we lonelier than ever?. [online] The Independent. Available at: https://www.independent.co.uk/life-style/health-and-families/features/the-loneliness-epidemic-more-connected-than-ever-but-feeling-more-alone-10143206.html [Accessed 1 Sep. 2019].

Holt-Lunstad, J., Smith, T., Baker, M., Harris, T. and Stephenson, D. (2015). Loneliness and Social Isolation as Risk Factors for Mortality. Perspectives on Psychological Science, 10(2), pp.227-237. https://doi.org/10.1177/1745691614568352

Leland, K. (2012). Loneliness Linked to Serious Health Problems and Death Among Elderly. [online] UC San Francisco. Available at: https://www.ucsf.edu/news/2012/06/98644/loneliness-linked-serious-health-problems-and-death-among-elderly [Accessed 1 Sep. 2019].

Perissinotto, C., Stijacic Cenzer, I. and Covinsky, K. (2012). Loneliness in Older Persons. Archives of Internal Medicine, 172(14). https://doi.org/10.1001/archinternmed.2012.1993

Ben Simon, E. and Walker, M. (2018). Sleep loss causes social withdrawal and loneliness. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-05377-0

Meditation is the practice of being in the here and now. Researchers have long observed that meditation, or the sense of presence, has the ability to:

• cultivate happiness;
• manage stress;
• improve performance at work, play, or life;
• establish a more authentic relationship with yourself and others.

Meditation has the ability to fundamentally change the way you live. Researchers have observed individuals who meditate and have discovered that the human mind wanders nearly half of the day. Moreover, research suggests that a wandering mind is a better predictor of happiness, independent of financial security. In essence, if your mind is wandering, you are much less likely to be happy. The sense of the present moment determines happiness.

Meditation develops two important skills to help keep the mind from wandering. The first is the ability to remain focused and attentive. The second, is the ability to recognize when the mind wanders so that it can gently be returned to the present moment.

An crucial concept to grasp before diving into meditation is the relaxation response. In the modern world, stress is chronic. The modern world is deluged with a vast amount of information and moves at such as fast pace, and this places everyone experiencing it in a state of stress. This often results in a surge of cortisol and adrenaline, hormones released by the adrenal glands, which activates the sympathetic nervous system, also known as the fight or flight response. As a result, the mind turns outward, seeking to evaluate and resolve anything that is the source of the stress. Unless you are relaxed, out of fight or flight, you cannot meditate. Activation of the parasympathetic nervous system must occur (the mind must be turned inward) in order to practice meditation. This balance can be achieved by learning the relaxation response. Relaxation is the first step to meditation.

The key to the relaxation response is noticing what happens in your body when the response is activated. What physiologic cues are revealed to you when you are relaxed? It is different for everyone. Some may experience a release of tension in the shoulders, others in the neck, many in the jaw. What is important is knowing when your body is relaxed and is ready to begin meditating.

In 1975, Herbert Benson wrote the book "The Relaxation Response". As a cardiologist, he noticed that many of his patients who had high blood pressure felt worse with the medications that he prescribed. Patients simply visiting him made matters worse. Benson discovered that stress was the culprit and relaxation was the cure. Benson reluctantly began working with transcendental meditation meditators because they claimed to be able to reduce their blood pressure. He observed that they were in fact correct. The meditators were able to successfully reduce their heart rate, metabolic rate, and breath rate. Benson coined this effect the "relaxation response". After researching this phenomena more he discovered that the relaxation response could be triggered easily, quickly, and anywhere.

Just as stress can be triggered in a variety of ways, so too can relaxation, including meditation. Benson later discovered four key components underlying the relaxation response:

1. A quiet environment
2. A comfortable position
3. A mental device (i.e., a sound to listen to, a mantra, an object to focus on)
4. A passive or allowing attitude

Eventually, Benson later discovered that only the last two are required, a mental device and an allowing attitude, to activate the relaxation response. This means that anyone can tap into the relaxation response anywhere and anytime.

How many hugs have you had today? Neuroeconomist Paul Zak, also known as "Dr. Love," recommends at least eight hugs a day to feel happier and more connected, as well as nurture relationships. As psychotherapist Virginia Satir said:

"We need 4 hugs a day for survival. We need 8 hugs a day for maintenance. We need 12 hugs a day for growth."

There may very well be a "hug threshold" that allows your body to produce ample amounts of oxytocin, which is released in response to physical touch such as breast-feeding, orgasm, hugs, snuggling, holding hands, partner dance, massage, bodywork, and prayer. The neuropeptide oxytocin, released by your pituitary gland, is a naturally occurring hormone in the body with incredibly powerful, health-giving properties.

This "love hormone" is also a key reason why the simple act of hugging is such an incredible way to enhance bonding with others but also boost your physical, and emotional, health.

Hugging increases levels of oxytocin, a neurotransmitter that acts as a hormone. This, in turn, has been observed to have beneficial physiological effects on your cardiovascular health and emotional happiness. One group of researchers observed, for example, a reduction in blood pressure among adults following a brief episode of warm contact with their partner. A 20-second hug, along with 10 minutes of hand-holding, reduces the harmful physical effects of stress, including its impact on your blood pressure and heart rate (Grewen, Anderson, Girdler & Light, 2003). This makes sense, since positive physical contact as hugging and  reduces cortisol, increases oxytocin, and lowers systolic blood pressure in stressful situations (Holt-Lunstad, Birmingham & Light, 2008). But researchers suggest there is even more to it than that.

The skin contains a network of tiny, egg-shaped rapidly adapting mechanoreceptors called Pacinian corpuscles with a large receptive field that can sense pressure and vibration and which are in contact with the brain through the vagus nerve. The vagus nerve winds its way through the body and provides input and receives sensation from the heart, liver, and digestive tract. (Freberg, 2006). The vagus nerve is also connected to oxytocin receptors. One theory is that stimulation of the vagus triggers an increase in oxytocin, which in turn leads to the cascade of health benefits.

A 10-second hug a day can lead to biochemical and physiological reactions in your body that can significantly improve your health. Hugging has been observed to stimulates your nervous system while decreasing feelings of loneliness, combating fear, increasing self-esteem, defusing tension, and showing appreciation. According to researchers, hugging has been observed to (Forsell & Åström, 2012):

• Lower the risk of heart disease
  
• Reduce stress
  
• Fight fatigue
• Boost your immune system
• Fight infections
• Ease depression

There's no doubt that physical touch of all kinds feels good. Whether it is a hug or a handshake, physical touch has a powerful effect on the human psyche resulting in us feeling happy, regardless if you are the toucher or touchee; connection, big or small, results in happiness.

Yet, many people are touch-deprived. One poll found that one-third of people receive no hugs on a daily basis while 75 percent said they wanted more hugs. Findings such as these, coupled with the emotional and health benefits of human touch, have led to the emergence of cuddle therapy centers, where people can pay for a lunchtime cuddle.

However, some have questioned whether or not physical contact from strangers has the same impact as those from someone you know and trust. While cuddling with a spouse or partner has been shown to boost satisfaction in relationships, some researchers have observed that hugs are only beneficial if trust is involved.

Neurophysiologist Jürgen Sandkühler, Head of the Centre for Brain Research at the Medical University of Vienna actually cautioned against worldwide "free hugs" campaigns (where strangers offer hugs to others), saying that this may be perceived as threatening and actually increase emotional burden and stress. However, significant benefits have been found from cuddling with a pet, which shows hugs don't have to only be between humans to be beneficial to your heart and overall health.

On average, people spend on hour a month hugging. That doesn't seem like much, but when you consider that the average hug is 3 seconds long, that adds up to be a lot of hugs.

And if you had any doubt about the importance of touch, consider that children who lack physical connection have delays in walking, talking, and reading. The act of hugging has a near-immediate impact on health, lowering your heart rate and inducing a calming effect while also leading to a more upbeat mood.

Touch is described as a universal language that can communicate distinct emotions with startling accuracy. Researchers observed that touch alone can reveal emotions including anger, fear, disgust, love, gratitude, and sympathy, with accuracy rates of up to 83 percent (Hertenstein, Holmes, McCullough & Keltner, 2009).

Hugging is a way to encourage your body to release oxytocin, and the more oxytocin your pituitary gland releases, the better able you are to handle life's stressors.

Moreover, oxytocin quite likely plays a role in why pet owners heal more quickly from illness, why couples live longer than singles, and why support groups work for people with addictions and chronic diseases.

Oxytocin has also been found to reduce the cravings of drug and alcohol addiction, as well as for sweets. It even has a positive influence on inflammation and wound healing. Even beyond this, regular hugs have the added benefit of:

• Cultivating patience and showing appreciation
• Activating the Solar Plexus Chakra, which stimulates your thymus gland (this may help balance your production of white blood cells)
• Stimulating dopamine, the pleasure hormone, and serotonin, for elevated mood
  
• Balancing out your nervous system for better parasympathetic balance

What can we all do to overcome the stress and anxiety that seems to pervade our news and daily interactions these days? In other words, how do we keep ourselves peaceful, healthy and thriving in these chaotic times we find ourselves in?

In this interview, Rosemary Gladstar shares a handful of herbs that can be used to keep your body centered and at peace – including one slightly controversial plant if you’re feeling adventurous. What is most striking about this interview is the deep wisdom that the legendary medicine woman shares. Her perspective is one worth listening to.

The stress-healing herbs Rosemary mentions are:

• Kava (a rising star for anxiety)
• Lemon Balm
• Chamomile
• Valerian
• Hops
• Hawthorne
• St John’s Wort
• Oats

Wim Hof is an autodidact and taught himself how to control his heart rate, breathing and blood circulation. All this is regulated by the autonomic nervous system. Conventional science says that the autonomic nervous system is a part of the body you just can´t control, yet Wim can, by steering his hypothalamus (an area in the brain which regulates the body temperature). Where the body temperature of an untrained person drops dangerously after exposing it to extreme cold, Wim is able to retain his core temperature around 37 degrees Celsius, constantly. Even after 1 hour and 52 minutes sitting in ice, Wim’s core temperature stays the same. Scientists around the world baffled by this exceptional performance. In the Netherlands, Prof. Maria Hopman of the UMC St Radboud Nijmegen examined Wim’s physiology as he was affected by the cold, while he was up to his neck in a cylinder filled with ice cubes.

Wim Hof, aka "The Iceman" holds the world record for the longest ice bath lasting over one hour and 52 minutes and 20 other world records for feats performed while withstanding the cold. He has climbed Mount Everest and Mount Kilimanjaro in just shorts and shoes. His method enables him to control his core body temperature and immune system, which can be learned by anyone including. Wim's ultimate goals are to end all disease to facilitate a paradigm shift towards health to promote care for our planet and to bring back love and happiness for all people by encouraging them to get in touch with the cold, and he plans to do all this under the scrutiny of science.

Humans are ancient beings living in a modern world. We have been hard-wired through evolution to require and seek contact with nature. A healthy, balanced life, physically and emotionally, requires this contact. Exposure to nature is one of the key foundations to a meaningful life. Indeed, a growing body of evidence overwhelmingly suggests connecting with nature is paramount for optimal health. 

Connection with nature has been associated with:

• Enhanced cognitive functioning
• Creativity and problem solving skills
• Reduced anxiety and stress
• Reduced blood pressure, therefore improved cardiovascular health
• Stronger immune system, including cancer-protective properties
• Improved mental health (reduced symptoms of ADD/ADHD, anger, etc.)
• Deeper sleep
• Enhanced quality of life and feeling of wellness

How much exposure to nature and outdoor natural environments is necessary, though, to ensure healthy development? Are there such things as minimum daily requirements of nature?

Determining a daily dose of exposure to nature is comparable to the nutrition pyramid that has been touted as a useful guide for the types and quantity of food consumption necessary to be healthy. It has been dubbed the Nature Pyramid,.

Referring to the standard nutritional pyramid, towards the top are things that are less healthful in larger quantities—meat, dairy, sugar—and should be consumed in the smallest proportions. Moving down the pyramid are elements in the diet—fruits and vegetables—that should be consumed more frequently and in greater quantity, and then finally the foods that contain the most nutrients that are needed on a daily basis. The Nature Pyramid would work in a similar way.

The Nature Pyramid challenges us to think about what the analogous quantities of nature are, and the types of nature exposures and experiences, needed to bring about a healthy life. Exposure to nature, that is direct personal contact with natural, is not an optional thing, but rather is a necessary and important element of a healthy human life. So, like the nutritional pyramid, what specifically is required for optimal health? What amounts of nature, different nature experiences, and exposure to different sorts of nature, together constitute a healthy existence? While researchers may lack the same degree of scientific certainly or confidence regarding a specific quantifiable amount of connection with nature necessary to ensure a healthy life, the pyramid at least begins to ask the right questions.

In 2005, in Last Child in the Woods, Richard Louv introduced the term nature-deficit disorder, not as a medical diagnosis, but as a way to describe the growing gap between humans and nature. Every day, our relationship with nature, or the lack of it, influences  our lives. This has always been true. But in the twenty-first century, our survival — or thrival — will require a transformative framework  for that relationship, a reunion of humans with the rest of nature.

The Nature  Principle is an amalgam of converging theories and trends as well as a  reconciliation with old truths. This principle holds that a reconnection to the natural world is fundamental to human health, wellness,  spirit, and survival. Primarily a statement of philosophy, the Nature Principle is supported by a growing body of theoretical, anecdotal, and empirical  research that describes the restorative power of nature  —   its impact  on our senses and intelligence; on our physical, psychological, and  spiritual health; and on the bonds of family, friendship, and the multispecies community.  What would our lives be like if our days and  nights were as immersed in nature as they are in electronics? How can each of us help create that life-enhancing world, not only in a hypothetical future, but right now, for our families and for ourselves? 

Our sense of urgency grows. In 2008, for the first time in history, more than half of the world’s population lived in towns and cities. The traditional ways that humans have experienced nature are vanishing, along with biodiversity. At the same time, our culture’s faith in technological immersion seems to have no limits, and we drift ever deeper into a sea of circuitry.  We consume breathtaking media accounts of the creation of synthetic  life, combining bacteria with human DNA; of microscopic machines designed to enter our bodies to fight biological invaders or to move in deadly clouds across the battlefields of war; of virtually-augmented reality; of futuristic houses in which we are surrounded by simulated reality transmitted from every wall. We even hear talk of the “transhuman” or “posthuman” era in which people are optimally enhanced by  technology, or of a “postbiological universe” where, as NASA’s Steven Dick puts it, “the majority of intelligent life has evolved beyond flesh  and blood intelligence.”

This collective disorder threatens our health, our spirit, our economy, and our future stewardship of the environment. Yet, despite what seem prohibitive odds, transformative change is possible. The loss that we feel, this truth that we  already know, sets the stage for a new age of nature. In fact, because of  the environmental challenges we face today, we may be  —   we had better  be  —   entering the most creative period in human history, a time defined  by a goal that includes but goes beyond sustainability to the renaturing of everyday life.

Do you or does someone you know experience nature-deficit disorder (NDD)? In this day in age, it is common to develop mild or severe forms of NDD. Here are several symptoms to look out for:

• Distraction - Foggy-headed and unfocused, distraction is a major symptom of NDD. Over-stimulated by tethered media devices and buzzing technologies, our attention-spans are being challenged more and more.
• Stress and Anxiety - Bogged down by endless todo lists? Does your work and daily life make it hard to slow down? Exhausted by our own agendas, we forget to take time to breathe. As a result, our bodies can experience varying symptoms from lack of sleep to high-blood pressure.     
  
• Depression - If you’ve ever had the winter blues, you know Seasonal Affective Disorder exists. Due to reduced sunlight and our sleeping patterns getting out of whack, we experience SAD. Combined with SAD, NDD may bring about depression in some, although it’s not always a visible symptom.  
• Obesity - Constantly indoors, our bodies can gain a few pounds and easily become overweight. What’s worse, obesity can lead to an endless list of other health-related issues.  The American Heart Association (AHA) gave a recent report that one in three children are considered overweight. Exceeding even drug abuse and smoking as a top health risk concern among parents, childhood obesity comes with added issues into adulthood: Type 2 diabetes, elevated cholesterol levels, higher blood pressures, lower self-esteem, and depression, among a few.     
  

At the bottom of the pyramid are forms of nature and outside life that should form the bulk of our daily experiences. Here there are the many ways in which we might daily enjoy and experience nature, both suburban and urban. As adults, a healthy nature diet requires being outside at least part of each day, walking, strolling, sitting, though it need not be in a remote and untouched national park or otherwise more pristine natural environment. Brief experiences and brief episodes of respite and connection are valuable to be sure: watching birds, hearing the outside sounds of life, and feeling the sun or breeze on one’s arms are important natural experiences, though perhaps brief and fleeting. Some of these experiences are visual and we know that even views of nature from office or home windows provides value. For school aged kids spending the day in a school drenched in full spectrum nature daylight is important and we know the evidence is compelling about the emotional value of this. Every day kids should spend some time outside, sometime playing and running outside, in direct contact with nature, weather, and the elements.

Moving from the bottom to the top of the pyramid also corresponds to an important temporal dimension. We need and should want to visit larger more remote parks and natural areas, but for most of us the majority of these larger parks will not be within distance of a daily trip. Each week, we should seek out a local park or area larger than your backyard. Each month, we should seek out a larger, national park. At the top of the pyramid are places and nature experiences that are profoundly important and enriching yet are more likely to happen less frequently, such as remote verdant areas, perhaps only several times a year. They are places of nature where immersion is possible, and where the intensity and duration of the nature experience are likely to be greater. And in between these temporal echelons (from daily to yearly) lie many of the nature opportunities and experiences that happen often on weekends or holidays or every few weeks, and perhaps without the degree of regularity that daily neighborhood nature experiences provide.

Like the food items higher on the food pyramid, the sites of nature highest on the Nature Pyramid might best be thought of occasional treats in our nature diet—good for us in small and measured servings, but actually unhealthy if consumed too often or in too great a quantity. For many urbanites from industrialized nations, large amounts of money and effort are expended visiting remote areas, from Patagonia, to the cloud forests of Costa Rica, to the Himalayas. It seems we relish and celebrate the ecologically remote and exotic. While they are deeply enjoyable nature experiences, to be sure, they come at a high planetary cost, as the energy and carbon footprint associated with jetting to these places is large indeed. No longer are such trips appreciated as unique and special “trips of a lifetime,” but fairly common and increasingly pedestrian jaunts to the affluent citizenry of the North. The Nature Pyramid sends a useful signal that travel to faraway nature may as glutinous and unhealthy as eating at the top of the food pyramid.

Forest bathing—or Shinrin-yoku Forest Therapy—is a Japanese healing method that allows an individual to immerse in the forest’s atmosphere. It stills the mind, leaving bathers focused and more alert. Researchers have observed that evergreen trees secret a natural chemical called phytoncide, which directly reduced stress levels and boosted immune systems in subjects (Li, 2009).

Researchers (Hansen, Jones and Tocchini, 2017) have determined with the healing components of Shinrin-yoku specifically hones in on the therapeutic effects on:

• the immune system function (increase in natural killer cells/cancer prevention);
• cardiovascular system (hypertension/coronary artery disease);
• the respiratory system (allergies and respiratory disease);
• depression and anxiety (mood disorders and stress);
• mental relaxation (Attention Deficit/Hyperactivity Disorder) and;
• human feelings of “awe” (increase in gratitude and selflessness)

Beatley, T. (2012). Exploring the Nature Pyramid – The Nature of Cities. [online] The Nature of Cities. Available at: https://www.thenatureofcities.com/2012/08/07/exploring-the-nature-pyramid/ [Accessed 21 Mar. 2018].

Hansen, M., Jones, R. and Tocchini, K. (2017). Shinrin-Yoku (Forest Bathing) and Nature Therapy: A State-of-the-Art Review. International Journal of Environmental Research and Public Health, 14(12), p.851. https://doi.org/10.3390/ijerph14080851

Kotera, Y., Richardson, M. & Sheffield, D. (2022). Effects of Shinrin-Yoku (Forest Bathing) and Nature Therapy on Mental Health: a Systematic Review and Meta-analysis. Int J Ment Health Addiction 20, 337–361. https://doi.org/10.1007/s11469-020-00363-4

Li, Q. (2009). Effect of forest bathing trips on human immune function. Environmental Health and Preventive Medicine, 15(1), pp.9-17. https://doi.org/10.1007/s12199-008-0068-3

Li Q. (2022). Effects of forest environment (Shinrin-yoku/Forest bathing) on health promotion and disease prevention -the Establishment of "Forest Medicine". Environ Health Prev Med. doi: 10.1265/ehpm.22-00160. PMID: 36328581; PMCID: PMC9665958.

Louv, R. (2012). The Nature Principle: Reconnecting with Life in a Virtual Age. Algonquin Books.

More than 2000 references on the biological responses to radio frequency (RF) and microwave radiation, published up to June 1971, have been well-documented by the U.S. Naval Medical Research Institute. Devices that emit RF and microwave radiation include, but is not limited to, cellphones, two-way radios, Wi-Fi routers, cellphone towers, smart watches, bluetooth devices, Smart meters, cordless cell phone base stations, wireless baby monitors, microwave ovens, and any WiFi-connected smart devices that receives and transmits data. Particular attention has been paid to the effects on man of non-ionizing radiation at these frequencies.

Reported Biological Phenomena (*Effects') and Some Clinical Manifestations Attributed to Microwave and Radio-Frequency Radiation

A. Heating of Organs*
(Applications: Diathermy, Electrosurgery, Electro-coagulation, Electrodesiccation, Electrotomy)

1. Whole Body (temperature regulation defects), Hyperpyrexia
2. Skin
3. Bone and Bone marrow
4. (a) Lens of Lye (cataractous lesions - due to the avascular nature of the lens which prevents adequate heat dissipation (b) Corneal damage also possible at extremely high frequencies
5. Cenitalia (tubular degeneration of testicles)
6. Brain
7. Sinuses
8. Metal Implants (burns near hip pins, etc.)

The effects are generally reversible except for 4a.

B.  Changes in physiologic function

1. Striated Muscle Contraction
2. Alteration of Diameter of Blood Vessels (increased Vascular elasticity, Dilation
3. Changes in Oxidative Processes in Tissues and Organs
4. Liver Enlargement
5. Altered Sensitivity to Drug Stimuli
6. Decreased Spermatogenesis (decreased fertility, to sterility)
7. Altered Sex Ratio of Births (more girls!)
8. Altered Menstrual Activity
9. Altered Fetal Development
10. Increased Lactation in Nursing Mothers
11. Reduction in Piuresis (Na+ excretion, via urine output)
12. Altered Renal function (decreased filtration in tubules)
13. Changes in Conditioned Reflexes
14. Increased Electrical Resistance of Skin
15. Changes in the Structure of Skin receptors of the (a) Digestive, and  (b) Blood Carrying Systems
16. Altered BIood Flow Rate
17. Alterations In the Biocurrents (EEG?) of the Cerebral Cortex (in animals)
18. Changes In the Rate of Clearance of Tagged Ions from Tissue
19. Reversible Structural Changes In the Cerebral Cortex and the Diencephalon
20. Electrocardiographic (EKG) Changes
21. Alterations In Sensitivity to Light, Sound, and Olfactory Stimuli
22. Functional (a) and Pathological (b) Changes in the Eyes: (a) decrease in size of blind spot, altered color recognition, changes in intraocular pressure, lacrimation, trembling of eye-lids; (b) less opacity and coagulation, altered tissue respiration, and altered reduction-oxidation processes
23. Myocardial Necrosis
24. Hemorrhage in Lungs, Liver, Gut, and Brain (At Fatal Levels of Radiation)
25. Generalized Degeneration of all Body Tissue of Radiation (At Fatal Levels of Radiation)
26. Loss of Anatomical Parts
27. Death
28. Dehydration
29. Altered Rate of Calcification of Certain Tissue

C.  Central Nervous System Effects

1. Headaches
2. Insomnia
3. Restlessness (Awake and During Sleep)
4. Electroencephalographic (EEG) Changes
5. Cranial Nerve Disorders
6. Pyramidal Tract Lesions
7. Conditioned Reflex Disorders
8. Vagomimetic Action of the Heart; Sympaticomimetic Action
9. Seizures, Convulsions

D.  Autonomic Nervous System Effects

1. Degenerative Disorders (e.g., alteration of heart rhythm)
2. Fatigue
3. Structural Alterations in the Synapses of the Vagus Nerve
4. Stimulation of Parasympathetic Nervous System (Bradycardia), and Inhibition of  the Sympathetic Nervous System

E.  Peripheral Nervous System Effects

1. Effects on Locomotor Nerves

F. Psychological Disorders ("Human Behavioral Studies") - the so-called "Psychophysiologic (and Psychosomatic) Responses"

1. Neurasthenia - (general "bad" feeling)
2. Depression
3. Impotence
4. Anxiety
5. Lack of Concentration
6. Hypochondria
7. Dizziness
8. Hallucinations
9. Sleepiness
10. Insomnia
11. Increased Irritability
12. Decreased Appetite
13. Loss of Memory
14. Scalp Sensations
15. Increased Fatigability
16. Chest pain
17. Tremor of the hand

G. Behavioral Changes (Animal)

1. Reflexive, Operant, Avoidance, and Discrimination Behaviors

H. Blood Disorders
changes in:

1. Blood and Bone Marrow
2. Phagocytic (polymorphs) and Bactericidal Functions
3. Hemolysis Rate (increase), (a shortened lifespan of cells)
4. Sedimentation Rate (increase), due to changes in serum concentration levels or amount of fibrinogen. (?))
5. Number of Erythrocytes (decrease), also number of lymphocytes
6. Blood Glucose Concentration (increase)
7. Blood Histamine Content
8. Cholesterol and Lipids
9. Gamma (also alpha and beta) Globulin, and Total Protein Concetration
10. Number of Eosinophils
11. Albumin/Globulin Ratio (decrease)
12. Hemopoiesis (rate of formation of blood corpuscles)
13. Leukopenia (increase in number of white cells), and Leukocytosis
14. Reticulocytosis

I. Vascular Disorders

1. Thrombosis
2. Hypertension

J. Enzyme and Other Biochemical Changes
Changes in activity of:

1. Cholinesterase
2. Phosphatase
3. Transaminase
4. Amylase
5. Carboxydismutase
6. Protein Denaturation
7. Toxin, Fungus, and Virus Inactivation (at high radiation dose levels), Bacteriostatic  Effect
8. Tissue Cultures Killed
9. Alteration In Rate of Cell Division
10. Increased Concentration of RNA in Lymphocytes, and Decreased Concentration in  Brain.  Liver,  and  Spleen
11. Changes in Pyruvic Acid, Lactic Acid, and Creatinine Excretions
12. Change in Concentration of Glycogen in Liver (Hlyperglycemia)
13. Alteration in Concentration of 17- Ketosteroids in Urine

K. Metabolic Disorders

1. Glycosuria (sugar in urine; related with blood sugar?)
2. Increase in Urinary Phenol (derivatives? DOPA?)
3. Alteration of rate of metabolic Enzymatic Processes
4. Altered Carbohydrate Metabolism

L. Gastro-Intestinal Disorders

1. Anorexia (loss of appetite)
2. Epigastric Pain
3. Constipation
4. Altered Secretion of Stomach "Digestive Juices"

M. Endocrine  Gland  Changes

1. Altered Pituitary Function
2. Hyperthyroidism
3. Thyroid Enlargement
4. Increased Uptake of Radioactive Iodine by Thyroid Gland
5. Altered Adrenal Cortex Activity
6. Decreased Corticosteroids in Blood
7. Decreased Glucocorticoidal Activity
8. Hypogonadism (usually decreased testosterone production)

N. Histological Changes

1. Changes in Tubular Epithelium of Testicles
2. Gross Changes

O. Genetic and Chromosomal Changes

1. Chromosome Aberrations (e.g., linear shortening, pseudochiasm, diploid structures, amitotic division, bridging, "sticky" chromosomes, irregularities in chromosomal envelope)
2. Mutations
3. Mongolism
4. Somatic Alterations (changes in cell not involving nucleus or chromosomes, cellular transformation)
5. Neoplastic Diseases (e.g*, tumors)

P. Pearl Chain Effect (Intracellular orientation of subcellular particles, and orientation of cellular and other (non-biologic) particles) Also, orientation of animals, birds, and fish in electromagnetic fields

Q. Miscellaneous Effects

1. Sparking between dental fillings
2. Peculiar metallic taste in mouth
3. Changes in Optical Activity of Colloidal Solutions
4. Treatment for Syphilis, Poliomyelitis, Skin Diseases
5. Loss of Hair
6. Brittleness of Hair
7. Sensations of Buzzing Vibrations, Pulsations, and Tickling About the Head and Ears
8. Copious Perspiration, Salivation, and Protrusion of Tongue
9. Changes in the Operation of Implanted Cardiac Pacemakers
10. Changes in Circadian Rhythms

Glaser, Z. (1971). Bibliography of reported biological phenomena ('effects') and clinical manifestations attributed to microwave and radio-frequency radiation. Navel Medical Research Institute. https://archive.org/details/DTIC_AD0750271/mode/2up?view=theater​

A growing body of evidence suggests that exercise is one of the most effective prevention and treatment strategies for depression.

A recent study, conducted over the course of 11 years, was designed to address whether exercise provides protection against new-onset depression and anxiety and if so, the intensity and amount of exercise required to gain protection and, lastly, the mechanisms that underlie any association.

Researchers evaluated and followed 33,908 adults, which were selected on the basis of having no symptoms of common mental disorder or limiting physical health conditions.
The researchers observed that regular leisure-time exercise was associated with reduced incidence of future depression but not anxiety. The majority of this protective effect occurred at low levels of exercise and was observed regardless of intensity. After adjusting for confounding variables, the results suggests that 12% of future cases of depression could have been prevented if all participants had engaged in at least 1 hour of physical activity each week. The social and physical health benefits of exercise explained a small proportion of the protective effect.

Many try to bolster their happiness through certain food choices, but this actually does not work, and Lustig provides compelling arguments that the foods you crave drive up dopamine and drive down serotonin. Rather, it’s experiences that make you happy. People can make you happy. You can make yourself happy. In his book, Lustig outlines a number of different strategies to become happier.

“Ultimately, the goal is [to increase] your serotonin,” he says. There are four ways to boost your serotonin, and they’re all free. They’re also things your grandmother likely told you to do. First and foremost is making human connections.

“Turns out that Facebook does not count as connection. When we’re talking about interpersonal connection, we’re talking about eye-to-eye,” Lustig says. “The facial emotions of the person you’re talking with activate a set of neurons in your brain called ‘mirror neurons,’ which are the drivers of empathy and specifically linked to serotonin.To be able to generate a feeling of empathy, which ultimately turns into contentment/happiness, you actually have to connect. You can’t do it over the internet. You can’t have a connection with ‘anonymous.’ It just doesn’t work.”

On the contrary, social media generate dopamine, associated with pleasure, and hence can drive addiction. The main problem is that when dopamine goes up, serotonin goes down. So, online communication is actually a major causative factor of unhappiness.

Lustig also elaborates on how companies — both food manufacturers and electronics companies — capitalize on the biology of dopamine versus serotonin to get us addicted to their products. There’s even a book on this topic written by Nir Eyal, called, “Hooked: How to Build Habit-Forming Products.”

There are three other ways, besides connecting, that boost serotonin and happiness. The remaining three of the four C’s are:

1. Contribute: Meaning the act of contributing to something greater than yourself; making a contribution to society. “You can get happiness and contentment from your job, but there are certain criteria that have to be met,” Lustig says. “Most people, unfortunately, have a boss who is not contributing to their happiness. The workplace is not usually the best place to achieve meaningful contentment.”

2. Cope: Lack of sleep, insufficient exercise and multitasking are all causes of unhappiness. Sleep is extremely important for healthy serotonin production. Here, avoiding exposure to electronic screens is important, as blue light inhibits melatonin production, thereby making sleep more elusive. Electronics will also disrupt your sleep and deteriorate your health by exposing you to unnecessary microwaves, discussed in this recent article on depression.

3. Cook: If you cook, you’re likely going to increase your tryptophan, reduce your refined sugar intake, and increase your omega-3 fats (anti-inflammatory) and fiber. Overall, this will result in improved gut health, which has tremendous impact on your mood and mental health.

“Numerous investigators … have shown that your gastrointestinal flora tell your brain what they want through signals that go through the bloodstream, and potentially even neural ones as well. If you do not feed your bacteria, you cannot get happy. Eating real food you prepare yourself is super important,” Lustig says.