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Awareness

Unveiling Obesogens: The Hidden Culprits in Weight Gain

3/31/2024

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In our modern world, where convenience often comes at a cost, the prevalence of obesogens – chemicals that disrupt the body's normal metabolism and contribute to weight gain – has emerged as a growing concern. From everyday products to industrial pollutants, obesogens permeate our environment, exerting subtle yet profound effects on our health and well-being.

Commonly encountered obesogens

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Among the many obesogens encountered in daily life, several stand out for their widespread use and potential health impacts:
  1. Bisphenol A (BPA): Found in plastics, food can linings, and thermal paper receipts, BPA is notorious for its endocrine-disrupting properties, which can interfere with hormone signaling and contribute to weight gain.
  2. Persistent Organic Pollutants (POPs): These industrial chemicals, including polychlorinated biphenyls (PCBs), can accumulate in the environment and the food chain, posing risks to human health and metabolism.
  3. Phthalates: Commonly used in plastics, personal care products, and food packaging, phthalates have been linked to disruptions in metabolic processes and adipose tissue function.
  4. Artificial Sweeteners: While marketed as calorie-free alternatives to sugar, artificial sweeteners like aspartame can disrupt gut microbiota and metabolic signaling pathways, potentially contributing to weight gain.
  5. Pesticides: Chemicals used in agriculture to control pests, such as glyphosate, can also disrupt endocrine function and metabolic regulation, posing risks to human health.
  6. Polychlorinated biphenyls (PCBs): PCBs are a group of synthetic organic chemicals formerly used in various industrial applications (electrical equipment, hydraulic systems, and heat transfer fluids, and various consumer products such as paints, sealants, and plastics), known for their persistence in the environment (soil, water, air) and their potential to cause adverse health effects in humans and wildlife.
  7. Processed foods: Processed foods often contain obesogens like Bisphenol A (BPA) and phthalates, which can leach into the food from packaging materials or be introduced during processing. These chemicals can disrupt metabolic function and contribute to weight gain, emphasizing the importance of choosing whole, unprocessed foods whenever possible to minimize exposure.
Bisphenol F
Bisphenol P
Bisphenol S
Antibiotics
Aspartame
Soy
Fructose
Cow Milk (Pasteurized) 
Thimerosal
Monosodium Glutamate (MSG)
β-hexachlorocyclohexane (βHCH)
2,5-dichlorophenol (2,5-DCP)

Mechanisms of Action

Obesogens exert their effects through various mechanisms, including:
  • Endocrine Disruption: Many obesogens interfere with hormone signaling pathways, particularly those involved in metabolism and adipogenesis (the formation of fat cells).
  • Disruption of Gut Microbiota: Some obesogens alter the composition and function of gut bacteria, which play a crucial role in metabolic regulation and energy balance.
  • Epigenetic Modifications: Exposure to obesogens during critical periods of development, such as prenatal or early childhood, can lead to long-lasting changes in gene expression that predispose individuals to weight gain and metabolic disorders.
  • Inflammation and Oxidative Stress: Obesogens can trigger inflammatory responses and increase oxidative stress, both of which are implicated in the pathogenesis of metabolic and mitochondrial disorders.
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Disruption of Metabolism via Mitochondria

Obesogens, through their pervasive presence in our environment, exert insidious effects on metabolic function, including the intricate workings of mitochondria – the cellular powerhouses responsible for energy production. By disrupting mitochondrial function, obesogens can contribute to metabolic dysregulation and, ultimately, weight gain.

Mitochondria play a central role in energy metabolism, converting nutrients into adenosine triphosphate (ATP), the primary source of cellular energy. However, exposure to obesogens can impair mitochondrial function through various mechanisms, including:
  • Oxidative Stress: Obesogens can promote the generation of reactive oxygen species (ROS) within mitochondria, leading to oxidative damage and dysfunction.
  • Mitochondrial Biogenesis: Some obesogens interfere with the process of mitochondrial biogenesis, the creation of new mitochondria, which is essential for maintaining optimal energy metabolism.
  • Respiratory Chain Dysfunction: Obesogens may disrupt the electron transport chain, a series of protein complexes within mitochondria that generate ATP, impairing energy production.
  • Mitochondrial Membrane Integrity: Obesogens can compromise the integrity of mitochondrial membranes, affecting the transport of ions and molecules critical for energy production.

​The disruption of mitochondrial function by obesogens can have profound implications for metabolic health and contribute to obesity through several pathways:
  1. Impaired Energy Expenditure: Dysfunctional mitochondria are less efficient at generating ATP, leading to reduced energy expenditure and a propensity for weight gain.
  2. Insulin Resistance: Mitochondrial dysfunction can impair insulin signaling pathways, contributing to insulin resistance, a hallmark of obesity and metabolic syndrome.
  3. Altered Lipid Metabolism: Mitochondria play a crucial role in lipid metabolism, including the breakdown of fatty acids for energy. Disrupted mitochondrial function can lead to aberrant lipid accumulation and adipogenesis, contributing to obesity.

causative relationship with health conditions

The impact of obesogens on human health extends beyond weight gain, with associations documented with various health conditions, including:
  • Obesity: Obesogens have been implicated in the global obesity epidemic, contributing to excess weight gain and adiposity. This includes being overweight, abdominal obesity (midsection fat), childhood and adult obesity.
  • Insulin Resistance and Diabetes: Disruption of metabolic pathways by obesogens can lead to insulin resistance, a precursor to type 2 diabetes.
  • Fatty Liver Disease: Chemical exposures, including those to bisphenols and phthalates, have been linked to the development of non-alcoholic fatty liver disease (NAFLD).

Additionally, obesogens are highly related to the following health conditions and physiologic imbalances:
Bisphenol Toxicity
Bisphenol-A Toxicity
​Chemically-Induced Liver Damage
​Fetal Origin of Adult Disease
​Fructose-Induced Toxicity
​Glyphosate Toxicity
​High Fat Diet
​Inflammation
Infant Chemical Exposures
Infant Nutrition
Insulin Resistance
​Oxidative Stress
​Phthalate Toxicity
​Prenatal Chemical Exposures
Triglycerides: Elevated

Unraveling the Role of Dysfunctional Adipose Tissue

Relatively little is known about the extent to which obesogen exposure programs dysfunctional adipose tissue that may store but not mobilize fat. However, emerging evidence suggests that obesogens may contribute to adipocyte dysfunction, leading to altered fat storage and metabolism. One potential underlying factor is suboptimal liver detoxification pathways due to inadequate micronutrient cofactors.
​
Inadequate levels of essential micronutrients, such as vitamins and minerals, can impair liver detoxification pathways responsible for metabolizing and eliminating obesogens from the body. As a result, obesogens may accumulate in adipose tissue, disrupting metabolic function and contributing to weight gain. Additionally, micronutrient deficiencies can compromise mitochondrial function, further exacerbating metabolic dysfunction and obesity risk.​

​​A Layman's Overview of Obesogens: Redefining the Weight Loss Paradigm

In the quest for weight loss, many of us often find ourselves fixating on calorie counting, fad diets, or intense workout regimens. However, what if I told you that the key to achieving a healthy weight isn't solely about shedding pounds but rather fixing your metabolism? Enter obesogens – a lesser-known yet influential factor in the obesity epidemic.

As mentioned, obesogens are chemicals found in our environment, ranging from pesticides and plastics to food additives and personal care products. These substances have the uncanny ability to disrupt our body's natural weight-regulating mechanisms, leading to weight gain and metabolic dysfunction. Instead of solely blaming calories in versus calories out, it's essential to recognize the role obesogens play in shaping our metabolism.

The Better Question: Fixing Metabolism

Rather than constantly asking ourselves, "How do I lose weight?" a more pertinent question would be:
"How do I fix my metabolism?"
Fixing metabolism involves addressing the root cause of weight gain – obesogen exposure and metabolic disruption. By eliminating or reducing our exposure to obesogens and ensuring our bodies receive essential micronutrients, we can optimize metabolic function and promote overall health.

The Two-Fold Solution

To achieve optimal health and maintain a healthy weight, a two-fold approach is necessary:
​

​1. Reduce Toxin Exposure: Minimize exposure to obesogens by making conscious choices in our daily lives. This includes opting for organic produce, using natural cleaning and personal care products, and avoiding plastic containers and food packaging whenever possible. By participating in a structured evidenced-based detoxification program, we in turn lower our toxic burden, and we can mitigate the adverse effects of obesogens on our metabolism.
Learn more about detoxification
2. Consume Micronutrients: Vital micronutrients, such as vitamins and minerals, serve as essential cofactors in metabolic pathways. Ensuring adequate intake of these micronutrients through a balanced diet rich in fruits, vegetables, whole grains, and lean proteins can support optimal metabolic function. Additionally, supplementation may be necessary to address any deficiencies and promote metabolic health.
​
The conventional approach to weight loss often overlooks the critical role obesogens play in metabolic dysfunction. Instead of solely focusing on calorie restriction or intense exercise, shifting our focus to fixing metabolism through toxin reduction and micronutrient consumption offers a more holistic and sustainable solution to achieving optimal health. By addressing the underlying factors contributing to metabolic disruption, we can pave the way for lasting weight management and overall well-being.

the harm of environmental toxins

The disruption of metabolic and mitochondrial function by obesogens represents a significant public health concern, with implications for obesity and metabolic disease. By understanding the mechanisms through which obesogens impair mitochondrial function and contribute to weight gain, researchers can develop targeted interventions to mitigate their adverse effects on metabolic health. Moreover, addressing underlying factors such as suboptimal liver detoxification pathways and micronutrient deficiencies is essential in combating the detrimental impact of obesogens on metabolic function and obesity prevalence.

The pervasive presence of obesogens in our environment underscores the need for greater awareness and regulation of these harmful chemicals. By minimizing exposure to obesogens and advocating for safer alternatives, we can mitigate their adverse effects on human health and combat the rising tide of obesity and metabolic disease. As we navigate the complexities of modern living, vigilance and informed consumer choices are essential in safeguarding our health and well-being against the hidden threats of obesogens.

Taking Action: The Integral Wellness Program​

For those seeking tangible solutions to combat the effects of obesogens and improve their overall well-being, the Integral Wellness Program offers a comprehensive approach to optimizing health and vitality. This flagship service provides personalized guidance and support in key areas of movement, nutrition, and lifestyle to directly enhance quality of life.
Learn more about the integral wellness program
Online/In-Person Guidance
One of the standout features of the Integral Wellness Program is its flexibility, offering both online and in-person consultations tailored to individual preferences and needs. Whether you prefer the convenience of virtual sessions or the hands-on approach of in-person coaching, our team of experienced wellness professionals is dedicated to supporting you every step of the way.
​Movement, Nutrition, and Lifestyle
The Integral Wellness Program takes a holistic approach to health, addressing modifiable factors and behaviors in three core areas:
  1. Movement: Through customized movement plans and exercise routines, participants are empowered to enhance physical fitness, flexibility, and overall mobility. Whether you're a seasoned athlete or new to fitness, our expert coaches will guide you towards achieving your movement goals safely and effectively.
  2. Nutrition: Central to the Integral Wellness Program is the emphasis on nutrient-dense foods and supplements to fuel and energize your body optimally. Our nutrition experts will work with you to develop personalized meal plans and dietary strategies tailored to your unique needs and preferences. By eliminating obesogen exposure and prioritizing wholesome, nourishing foods, you can support metabolic health and achieve sustainable weight management.
  3. Lifestyle: Beyond movement and nutrition, the Integral Wellness Program addresses lifestyle factors that contribute to overall well-being. From stress management techniques to sleep hygiene practices, our holistic approach encompasses all aspects of lifestyle optimization to promote balance, resilience, and vitality.

​Augmenting the Health Process
By participating in the Integral Wellness Program, you'll not only gain valuable knowledge and skills to navigate the challenges of modern living but also receive ongoing support and accountability to stay on track towards your health goals. Through targeted interventions aimed at eliminating obesogen exposure and promoting healthy behaviors, you can unlock your body's full potential and thrive in all aspects of life.
Learn more about the integral wellness program
The Integral Wellness Program offers a transformative journey towards optimal health and vitality. By prioritizing movement, nutrition, and lifestyle modifications, participants can take proactive steps to combat the effects of obesogens and reclaim control over their well-being. With the guidance and support of our dedicated wellness professionals, you'll embark on a path of self-discovery, empowerment, and lasting transformation.

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Dr. Zach Bush: The Reincarnation of Hippocrates

12/29/2020

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Zach Bush MD is a physician specializing in internal medicine, endocrinology and hospice care. He is an internationally recognized educator and thought leader on the microbiome as it relates to health, disease, and food systems. Dr Zach founded Seraphic Group and the nonprofit Farmer’s Footprint to develop root-cause solutions for human and ecological health. His passion for education reaches across many disciplines, including topics such as the role of soil and water ecosystems in human genomics, immunity, and gut/brain health. His education has highlighted the need for a radical departure from chemical farming and pharmacy, and his ongoing efforts are providing a path for consumers, farmers, and mega-industries to work together for a healthy future for people and planet.

Show Notes
  • A trip to the Philippines changed Zack’s life mission and how he viewed allopathic medicine afterward. (10:07)
  • “The scientific method is nothing more than a technique for exploring truth, but at no point is science a body of knowledge or truth…” (28:16)
  • Zach’s bedrock spiritual philosophy: I am. (41:06)
  • Homo sapiens is an adaptive species and not a stagnant one. (55:09)
  • What’s the difference between a rishi and a reishi mushroom? (1:14:00)
  • A quantum physics fellowship. (1:23:20)
  • Healing relationships at death’s door. (1:36:32)
  • Random event generators and the death of George Floyd. (1:40:15)
  • Do humans have the raw potential to co-create something magnificent? (1:50:21)
Resources
  • Zack’s articles co-written with Deepak Chopra on June 1 and June 8 in the SF Gate
  • Antoine Béchamp vs. Louis Pasteur
  • The work of J.R.R. Tolkien and John Archibald Wheeler
  • Mycorrhiza
  • Superstring theory
  • The Abdominal and Pelvic Brain by Byron Robinson
  • Intestinal Gardening for the Prolongation of Youth by James Empringham
  • Universal Sufism by H.J. Witteveen and Scott Sattler
  • Streams of Wisdom by Dustin DiPerna and Ken Wilbur
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