Recent breakthrough studies have shone a light on the intriguing link between our microbiome – the diverse community of microorganisms residing in our gut and mouth – and the secret to a longer, healthier life. Scientists have long suspected that our genes, environment, and internal factors like the microbiome play a role in determining how long we live, but the specifics remained elusive. Now, thanks to cutting-edge research, we're getting closer to unraveling the mysteries of longevity. In this groundbreaking exploration, scientists employed a sophisticated approach called Mendelian randomization (MR) to delve into the intricate relationships between the human microbiome and longevity. By analyzing genetic data from large cohorts, they uncovered some compelling associations that shed light on the microbial players in the quest for a longer life. The Gut Chronicles: Microbial Superstars and CulpritsThe gut microbiome, a bustling metropolis of bacteria, has been a focal point in the quest for longevity. The study identified certain gut microbes as potential champions in the battle against aging. Microbial heroes like Coriobacteriaceae, Oxalobacter, and the probiotic Lactobacillus amylovorus were found to be positively linked to increased odds of longevity. On the flip side, a few gut microbes emerged as potential antagonists, with names like Fusobacterium nucleatum, Coprococcus, Streptococcus, Lactobacillus, and Neisseria negatively associated with longevity. These microbial foes might have a role in determining how gracefully we age. Oral Health: More Than Just a Pretty SmileThe study didn't stop at the gut; it extended its gaze to the oral microbiome, a less-explored but equally important realm. The findings suggested a fascinating connection between the oral microbiome and longevity. Specific oral bacteria were identified as potential influencers in the longevity game. Interestingly, the research hinted at a lower gut microbial diversity among centenarians (diversity appears to lower with age), but no significant difference in their oral microbiota. This finding underscores the importance of tracking the movements of these beneficial microbes across different parts of the body for a longer and healthier life. Decoding the Genetic Blueprint for LongevityThe study leveraged Mendelian randomization to unravel the causality between the microbiome and longevity. This approach, using genetic variants as tools, allowed scientists to explore the potential causal links between specific microbial features and the length of our lives. The bidirectional analyses provided a wealth of information, not only pinpointing specific microbes associated with longevity but also revealing the microbial preferences of genetically longevous individuals. For instance, genetic predisposition to longevity correlated with a higher abundance of Prevotella and a lower abundance of Bacteroides, suggesting a potential link between dietary choices and a longer life. Microbes and Diseases: Unraveling the We The study didn't just stop at longevity; it ventured into the realm of diseases. Certain microbes associated with longevity were found to have correlations with specific diseases. For example, Coriobacteriaceae, linked to longevity, was significantly reduced in patients with heart failure, suggesting a potential protective role against cardiovascular diseases. This "microbiota—disease—longevity" axis provides a nuanced understanding of how our microbial companions might influence not only our lifespan but also our susceptibility to various health conditions. What's Next in the Quest for a Longer LifeWhile the study opens exciting new avenues, there are some limitations to consider. The identified causalities didn't all reach statistical significance due to the vast number of microbial features tested. However, the robustness of the findings was supported by the replication of several identified causal links in independent datasets. Moving forward, researchers aim to collect more comprehensive individual-level data, including microbiome profiles, genetics, socio-economic factors, behaviors, and environmental influences. This holistic approach will help tease apart the individual contributions of these factors to longevity. In conclusion, this pioneering study, using Mendelian randomization, has provided us with a roadmap to explore the intricate connections between our microbiome and the quest for a longer, healthier life. As we unlock the secrets hidden in our genes and microbes, we inch closer to personalized approaches for healthy aging and interventions that could extend our time on this planet. referencesLiu, Xiaomin, et al. “Mendelian Randomization Analyses Reveal Causal Relationships between the Human Microbiome and Longevity.” Scientific Reports, vol. 13, no. 1, 29 Mar. 2023, p. 5127, www.nature.com/articles/s41598-023-31115-8, https://doi.org/10.1038/s41598-023-31115-8.
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In an update to its 2007 scientific statement, the American Heart Association (AHA) emphasizes the significant and multifaceted benefits of resistance training (RT) on cardiovascular health. Contrary to the misconception that RT solely enhances muscle mass and strength, the statement highlights the favorable physiological and clinical effects of this form of exercise on cardiovascular disease (CVD) and associated risk factors. The scientific statement aims to provide comprehensive insights into the impact of RT, either alone or in combination with aerobic training, on traditional and nontraditional CVD risk factors. More is not always betterEpidemiological evidence suggests that RT is associated with a lower risk of all-cause mortality and CVD morbidity and mortality. Adults who participate in RT have ≈15% lower risk of all-cause mortality and 17% lower risk of CVD, compared with adults who report no RT. Approximately 30 to 60 minutes per week of RT is associated with the maximum risk reduction for all-cause mortality and incident CVD. Notice this "U" shape in the curve when examining the relationship between RT and morbidity and mortality. This curve suggests that some RT is clearly beneficial, but has the volume of RT increases past a certain point the benefits drop and it becomes harmful. The concept of a "biphasic response" is fundamental to understanding hormesis. It describes the characteristic dose-response relationship observed in hormetic processes, where a substance or stressor elicits opposite effects at low and high doses. The response can be visualized as a U-shaped or J-shaped curve, illustrating the beneficial effects at low doses and potential harm at higher doses. Benefits of RT on Traditional CVD Risk FactorsThe AHA's scientific statement underscores the positive influence of RT on traditional CVD risk factors, including blood pressure (BP), glycemia, lipid profiles, and body composition. Numerous studies indicate that engaging in RT is associated with reduced resting BP, improved glycemic control, and favorable alterations in lipid profiles, contributing to a lower risk of all-cause mortality and CVD morbidity. Despite recommendations suggesting 2 days per week of RT, only 28% of U.S. adults adhere to this guideline, highlighting the need for increased awareness and promotion. RT and resting blood pressureRT has demonstrated the ability to reduce resting BP across diverse populations, with notable benefits observed in individuals with prehypertension and hypertension. The mechanisms behind these benefits include enhancements in endothelial function, vasodilatory capacity, and vascular conductance. The reductions in BP achieved through RT are comparable to those achieved with antihypertensive medications. RT and GlycemiaRT shows promise in improving glycemia and insulin resistance, leading to a lower incidence of diabetes. The evidence suggests a nonlinear dose-response association, with up to 60 minutes per week of RT associated with the maximum risk reduction for diabetes. RT and Lipid ProfilesWhile the effect on lipid profiles is modest, RT results in favorable changes in high-density lipoprotein cholesterol, total cholesterol, and triglycerides. These improvements are more pronounced in older adults and those with elevated cardiometabolic risk. Rt, Body composition, and weightRT positively influences body composition by increasing lean body mass and reducing body fat percentage. It is particularly effective in overweight or obese individuals, contributing to increased metabolic rate and mitigating weight gain over time. Benefits of RT on Nontraditional CVD Risk FactorsIn addition to traditional risk factors, the scientific statement highlights the potential mechanisms by which RT positively affects nontraditional CVD risk factors. These include increased cardiorespiratory fitness, improved endothelial function, and potential benefits for sleep quality, psychological health, and well-being. The AHA's updated scientific statement reinforces the pivotal role of resistance training in cardiovascular health, providing a comprehensive overview of its impact on both traditional and nontraditional risk factors. As the evidence supporting RT's benefits continues to grow, the statement serves as a valuable resource for clinicians and public health professionals, offering practical strategies for promoting and prescribing resistance training to enhance cardiovascular health in diverse populations. ReferencesPaluch, Amanda E, et al. “Resistance Exercise Training in Individuals with and without Cardiovascular Disease: 2023 Update: A Scientific Statement from the American Heart Association.” Circulation, 7 Dec. 2023, https://doi.org/10.1161/cir.0000000000001189. Accessed 11 Dec. 2023.
Momma H, Kawakami R, Honda T, Sawada SS. Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies. Br J Sports Med. 2022 Jul;56(13):755-763. doi: 10.1136/bjsports-2021-105061. Epub 2022 Feb 28. PMID: 35228201; PMCID: PMC9209691. We’ve built an entire economy, not just in the United States but the entire Western civilization, on healthcare. For thousands of years, real control over populations has been around their food. Today, with billions of souls on the planet, controlling food has become a massive business and a means of ultimate political control. Between 1982 and 2000, something changed in our environment, overwhelming the immune system of the population. Diseases in different organ systems started going epidemic simultaneously, challenging the notion of a thousand different diseases.
In the late 1800s, we changed the way we farmed, leading to a disrespect for crop rotation and soil health. This disrespect for soil health resulted in the Dust Bowl of the 1920s and 30s, pushing us to outsource our food production and rely on imported food. After World War II, with a surplus of petroleum, we started producing chemical-based fertilizers, leading to the Green Revolution. While plants turned green due to nitrogen and phosphorus, they lacked essential nutrients and medicine. This deficiency weakened plants, making them susceptible to diseases and pests. The chemical industry introduced pesticides and herbicides (including #Glyphosate), creating a co-dependent relationship between farmers and chemical solutions. Similarly, in healthcare, we’ve become dependent on drugs to manage symptoms, creating a cycle of side effects and more medications. The epidemic rise in diseases like autism, Alzheimer’s, Parkinson’s, and autoimmune disorders signals a deeper problem, challenging our understanding of the root cause of diseases. It’s time to reconsider our approach to health, starting with understanding the importance of soil health and nutrition. Just as respecting soil is crucial for healthy crops, prioritizing our body’s nutritional needs is fundamental for overall well-being. Let’s shift our focus from symptom management to addressing the root cause, promoting a holistic approach to health. Zach Bush, MD is triple board-certified physician specializing in internal medicine, endocrinology and hospice care. He is the founder of Seraphic Group, an organization devoted to developing root-cause solutions for human and ecological health in the sectors of big farming, big pharma, and Western Medicine at large. And he is also the founder of Farmers Footprint https://farmersfootprint.us/, a non-profit coalition of farmers, educators, doctors, scientists, and business leaders aiming to expose the deleterious human and environmental impacts of chemical farming and pesticide reliance - while simultaneously offering a path forward through regenerative agricultural practices. |
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