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Awareness

Exploring the Impact of Protein Ingestion on Muscle Protein Synthesis following exercise

7/27/2024

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When it comes to optimizing muscle recovery and growth, the role of protein intake has always been a hot topic. The belief has been that the anabolic (muscle-building) response to feeding post-exercise is short-lived and that consuming more protein than a certain amount results in the excess being wasted through oxidation. However, recent research challenges this notion, offering new insights into how our bodies handle protein after exercise.
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Key Findings from Recent Research

  1. Sustained Anabolic Response with High Protein Intake:

    Extended Anabolic Period: The study found that consuming a large amount of protein (100 g) leads to a prolonged anabolic response lasting over 12 hours. This is significantly longer than the response seen with smaller protein doses (e.g., 25 g).

    Increased Protein Synthesis: The ingestion of 100 g of protein resulted in greater muscle protein synthesis and whole-body protein synthesis rates compared to 25 g. This means more of the ingested protein was used for muscle building over a longer period.

  2. Minimal Impact on Amino Acid Oxidation:
    Contrary to the belief that excess protein is oxidized and wasted, the study demonstrated that protein ingestion has a negligible impact on amino acid oxidation rates. This suggests that the body effectively utilizes the majority of the ingested protein for muscle protein synthesis rather than breaking it down for energy.

  3. No Increase in Muscle Protein Breakdown:
    The study showed that consuming large amounts of protein did not increase muscle protein breakdown rates. This is important as it indicates that the additional protein supports muscle growth without causing muscle degradation.

  4. Efficient Utilization of Exogenous Amino Acids:
    The research highlighted that exogenous (dietary-derived) amino acids are efficiently incorporated into muscle proteins, contributing significantly to postprandial protein accretion. This efficient utilization underscores the value of dietary protein in supporting muscle anabolism.​​
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Practical Implications

These findings suggest that the body's capacity to utilize dietary protein for muscle synthesis is greater than previously thought. For those looking to maximize muscle growth and recovery, it may be beneficial to consume larger protein meals, especially post-exercise, rather than strictly adhering to the conventional wisdom of limiting protein intake to 20-25 g per meal.

Holistic Approach to Protein Consumption

Understanding the extended anabolic response to higher protein intake can influence dietary strategies for athletes, bodybuilders, and individuals looking to enhance their muscle mass and recovery. It also supports the flexibility in meal timing and frequency, suggesting that consuming larger protein meals less frequently can still provide substantial muscle-building benefits.

Opt for animal products that are high quality. Low quality animal products can certainly cause more harm, due to environmental contamination. Bovine sources of protein are best selected if they are pasture-raised (grass-fed and grass-finished). Fish is best selected wild and line-caught, as fresh as possible.


In summary, recent research challenges the traditional view of protein metabolism post-exercise, showing that higher protein intake can sustain an anabolic response for a longer period without increasing amino acid oxidation or muscle protein breakdown. This opens up new possibilities for dietary strategies aimed at optimizing muscle protein synthesis and overall muscle health.

references

Jorn Trommelen, et al. “The Anabolic Response to Protein Ingestion during Recovery from Exercise Has No Upper Limit in Magnitude and Duration in Vivo in Humans.” Cell Reports Medicine, vol. 4, no. 12, 1 Dec. 2023, pp. 101324–101324, https://doi.org/10.1016/j.xcrm.2023.101324.
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Unveiling Obesogens: The Hidden Culprits in Weight Gain

3/31/2024

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In our modern world, where convenience often comes at a cost, the prevalence of obesogens – chemicals that disrupt the body's normal metabolism and contribute to weight gain – has emerged as a growing concern. From everyday products to industrial pollutants, obesogens permeate our environment, exerting subtle yet profound effects on our health and well-being.

Commonly encountered obesogens

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Among the many obesogens encountered in daily life, several stand out for their widespread use and potential health impacts:
  1. Bisphenol A (BPA): Found in plastics, food can linings, and thermal paper receipts, BPA is notorious for its endocrine-disrupting properties, which can interfere with hormone signaling and contribute to weight gain.
  2. Persistent Organic Pollutants (POPs): These industrial chemicals, including polychlorinated biphenyls (PCBs), can accumulate in the environment and the food chain, posing risks to human health and metabolism.
  3. Phthalates: Commonly used in plastics, personal care products, and food packaging, phthalates have been linked to disruptions in metabolic processes and adipose tissue function.
  4. Artificial Sweeteners: While marketed as calorie-free alternatives to sugar, artificial sweeteners like aspartame can disrupt gut microbiota and metabolic signaling pathways, potentially contributing to weight gain.
  5. Pesticides: Chemicals used in agriculture to control pests, such as glyphosate, can also disrupt endocrine function and metabolic regulation, posing risks to human health.
  6. Polychlorinated biphenyls (PCBs): PCBs are a group of synthetic organic chemicals formerly used in various industrial applications (electrical equipment, hydraulic systems, and heat transfer fluids, and various consumer products such as paints, sealants, and plastics), known for their persistence in the environment (soil, water, air) and their potential to cause adverse health effects in humans and wildlife.
  7. Processed foods: Processed foods often contain obesogens like Bisphenol A (BPA) and phthalates, which can leach into the food from packaging materials or be introduced during processing. These chemicals can disrupt metabolic function and contribute to weight gain, emphasizing the importance of choosing whole, unprocessed foods whenever possible to minimize exposure.
Bisphenol F
Bisphenol P
Bisphenol S
Antibiotics
Aspartame
Soy
Fructose
Cow Milk (Pasteurized) 
Thimerosal
Monosodium Glutamate (MSG)
β-hexachlorocyclohexane (βHCH)
2,5-dichlorophenol (2,5-DCP)

Mechanisms of Action

Obesogens exert their effects through various mechanisms, including:
  • Endocrine Disruption: Many obesogens interfere with hormone signaling pathways, particularly those involved in metabolism and adipogenesis (the formation of fat cells).
  • Disruption of Gut Microbiota: Some obesogens alter the composition and function of gut bacteria, which play a crucial role in metabolic regulation and energy balance.
  • Epigenetic Modifications: Exposure to obesogens during critical periods of development, such as prenatal or early childhood, can lead to long-lasting changes in gene expression that predispose individuals to weight gain and metabolic disorders.
  • Inflammation and Oxidative Stress: Obesogens can trigger inflammatory responses and increase oxidative stress, both of which are implicated in the pathogenesis of metabolic and mitochondrial disorders.
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Disruption of Metabolism via Mitochondria

Obesogens, through their pervasive presence in our environment, exert insidious effects on metabolic function, including the intricate workings of mitochondria – the cellular powerhouses responsible for energy production. By disrupting mitochondrial function, obesogens can contribute to metabolic dysregulation and, ultimately, weight gain.

Mitochondria play a central role in energy metabolism, converting nutrients into adenosine triphosphate (ATP), the primary source of cellular energy. However, exposure to obesogens can impair mitochondrial function through various mechanisms, including:
  • Oxidative Stress: Obesogens can promote the generation of reactive oxygen species (ROS) within mitochondria, leading to oxidative damage and dysfunction.
  • Mitochondrial Biogenesis: Some obesogens interfere with the process of mitochondrial biogenesis, the creation of new mitochondria, which is essential for maintaining optimal energy metabolism.
  • Respiratory Chain Dysfunction: Obesogens may disrupt the electron transport chain, a series of protein complexes within mitochondria that generate ATP, impairing energy production.
  • Mitochondrial Membrane Integrity: Obesogens can compromise the integrity of mitochondrial membranes, affecting the transport of ions and molecules critical for energy production.

​The disruption of mitochondrial function by obesogens can have profound implications for metabolic health and contribute to obesity through several pathways:
  1. Impaired Energy Expenditure: Dysfunctional mitochondria are less efficient at generating ATP, leading to reduced energy expenditure and a propensity for weight gain.
  2. Insulin Resistance: Mitochondrial dysfunction can impair insulin signaling pathways, contributing to insulin resistance, a hallmark of obesity and metabolic syndrome.
  3. Altered Lipid Metabolism: Mitochondria play a crucial role in lipid metabolism, including the breakdown of fatty acids for energy. Disrupted mitochondrial function can lead to aberrant lipid accumulation and adipogenesis, contributing to obesity.

causative relationship with health conditions

The impact of obesogens on human health extends beyond weight gain, with associations documented with various health conditions, including:
  • Obesity: Obesogens have been implicated in the global obesity epidemic, contributing to excess weight gain and adiposity. This includes being overweight, abdominal obesity (midsection fat), childhood and adult obesity.
  • Insulin Resistance and Diabetes: Disruption of metabolic pathways by obesogens can lead to insulin resistance, a precursor to type 2 diabetes.
  • Fatty Liver Disease: Chemical exposures, including those to bisphenols and phthalates, have been linked to the development of non-alcoholic fatty liver disease (NAFLD).

Additionally, obesogens are highly related to the following health conditions and physiologic imbalances:
Bisphenol Toxicity
Bisphenol-A Toxicity
​Chemically-Induced Liver Damage
​Fetal Origin of Adult Disease
​Fructose-Induced Toxicity
​Glyphosate Toxicity
​High Fat Diet
​Inflammation
Infant Chemical Exposures
Infant Nutrition
Insulin Resistance
​Oxidative Stress
​Phthalate Toxicity
​Prenatal Chemical Exposures
Triglycerides: Elevated

Unraveling the Role of Dysfunctional Adipose Tissue

Relatively little is known about the extent to which obesogen exposure programs dysfunctional adipose tissue that may store but not mobilize fat. However, emerging evidence suggests that obesogens may contribute to adipocyte dysfunction, leading to altered fat storage and metabolism. One potential underlying factor is suboptimal liver detoxification pathways due to inadequate micronutrient cofactors.
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Inadequate levels of essential micronutrients, such as vitamins and minerals, can impair liver detoxification pathways responsible for metabolizing and eliminating obesogens from the body. As a result, obesogens may accumulate in adipose tissue, disrupting metabolic function and contributing to weight gain. Additionally, micronutrient deficiencies can compromise mitochondrial function, further exacerbating metabolic dysfunction and obesity risk.​

​​A Layman's Overview of Obesogens: Redefining the Weight Loss Paradigm

In the quest for weight loss, many of us often find ourselves fixating on calorie counting, fad diets, or intense workout regimens. However, what if I told you that the key to achieving a healthy weight isn't solely about shedding pounds but rather fixing your metabolism? Enter obesogens – a lesser-known yet influential factor in the obesity epidemic.

As mentioned, obesogens are chemicals found in our environment, ranging from pesticides and plastics to food additives and personal care products. These substances have the uncanny ability to disrupt our body's natural weight-regulating mechanisms, leading to weight gain and metabolic dysfunction. Instead of solely blaming calories in versus calories out, it's essential to recognize the role obesogens play in shaping our metabolism.

The Better Question: Fixing Metabolism

Rather than constantly asking ourselves, "How do I lose weight?" a more pertinent question would be:
"How do I fix my metabolism?"
Fixing metabolism involves addressing the root cause of weight gain – obesogen exposure and metabolic disruption. By eliminating or reducing our exposure to obesogens and ensuring our bodies receive essential micronutrients, we can optimize metabolic function and promote overall health.

The Two-Fold Solution

To achieve optimal health and maintain a healthy weight, a two-fold approach is necessary:
​

​1. Reduce Toxin Exposure: Minimize exposure to obesogens by making conscious choices in our daily lives. This includes opting for organic produce, using natural cleaning and personal care products, and avoiding plastic containers and food packaging whenever possible. By participating in a structured evidenced-based detoxification program, we in turn lower our toxic burden, and we can mitigate the adverse effects of obesogens on our metabolism.
Learn more about detoxification
2. Consume Micronutrients: Vital micronutrients, such as vitamins and minerals, serve as essential cofactors in metabolic pathways. Ensuring adequate intake of these micronutrients through a balanced diet rich in fruits, vegetables, whole grains, and lean proteins can support optimal metabolic function. Additionally, supplementation may be necessary to address any deficiencies and promote metabolic health.
​
The conventional approach to weight loss often overlooks the critical role obesogens play in metabolic dysfunction. Instead of solely focusing on calorie restriction or intense exercise, shifting our focus to fixing metabolism through toxin reduction and micronutrient consumption offers a more holistic and sustainable solution to achieving optimal health. By addressing the underlying factors contributing to metabolic disruption, we can pave the way for lasting weight management and overall well-being.

the harm of environmental toxins

The disruption of metabolic and mitochondrial function by obesogens represents a significant public health concern, with implications for obesity and metabolic disease. By understanding the mechanisms through which obesogens impair mitochondrial function and contribute to weight gain, researchers can develop targeted interventions to mitigate their adverse effects on metabolic health. Moreover, addressing underlying factors such as suboptimal liver detoxification pathways and micronutrient deficiencies is essential in combating the detrimental impact of obesogens on metabolic function and obesity prevalence.

The pervasive presence of obesogens in our environment underscores the need for greater awareness and regulation of these harmful chemicals. By minimizing exposure to obesogens and advocating for safer alternatives, we can mitigate their adverse effects on human health and combat the rising tide of obesity and metabolic disease. As we navigate the complexities of modern living, vigilance and informed consumer choices are essential in safeguarding our health and well-being against the hidden threats of obesogens.

Taking Action: The Integral Wellness Program​

For those seeking tangible solutions to combat the effects of obesogens and improve their overall well-being, the Integral Wellness Program offers a comprehensive approach to optimizing health and vitality. This flagship service provides personalized guidance and support in key areas of movement, nutrition, and lifestyle to directly enhance quality of life.
Learn more about the integral wellness program
Online/In-Person Guidance
One of the standout features of the Integral Wellness Program is its flexibility, offering both online and in-person consultations tailored to individual preferences and needs. Whether you prefer the convenience of virtual sessions or the hands-on approach of in-person coaching, our team of experienced wellness professionals is dedicated to supporting you every step of the way.
​Movement, Nutrition, and Lifestyle
The Integral Wellness Program takes a holistic approach to health, addressing modifiable factors and behaviors in three core areas:
  1. Movement: Through customized movement plans and exercise routines, participants are empowered to enhance physical fitness, flexibility, and overall mobility. Whether you're a seasoned athlete or new to fitness, our expert coaches will guide you towards achieving your movement goals safely and effectively.
  2. Nutrition: Central to the Integral Wellness Program is the emphasis on nutrient-dense foods and supplements to fuel and energize your body optimally. Our nutrition experts will work with you to develop personalized meal plans and dietary strategies tailored to your unique needs and preferences. By eliminating obesogen exposure and prioritizing wholesome, nourishing foods, you can support metabolic health and achieve sustainable weight management.
  3. Lifestyle: Beyond movement and nutrition, the Integral Wellness Program addresses lifestyle factors that contribute to overall well-being. From stress management techniques to sleep hygiene practices, our holistic approach encompasses all aspects of lifestyle optimization to promote balance, resilience, and vitality.

​Augmenting the Health Process
By participating in the Integral Wellness Program, you'll not only gain valuable knowledge and skills to navigate the challenges of modern living but also receive ongoing support and accountability to stay on track towards your health goals. Through targeted interventions aimed at eliminating obesogen exposure and promoting healthy behaviors, you can unlock your body's full potential and thrive in all aspects of life.
Learn more about the integral wellness program
The Integral Wellness Program offers a transformative journey towards optimal health and vitality. By prioritizing movement, nutrition, and lifestyle modifications, participants can take proactive steps to combat the effects of obesogens and reclaim control over their well-being. With the guidance and support of our dedicated wellness professionals, you'll embark on a path of self-discovery, empowerment, and lasting transformation.

references


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Navigating Hormesis: Embracing the Balance Between Stress and Strength for Optimal Health

12/21/2023

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In the intricate dance of biological responses to stress, hormesis emerges as a captivating phenomenon, challenging conventional notions of dose-response relationships. This blog post delves into the fascinating world of hormesis, where the subtle interplay between stressors and adaptive responses shapes our understanding of health and resilience.
Learn more about Hormesis

The Hormetic Curve: Unveiling the U-Shaped Story

Explore the dynamics of hormesis through the lens of a U-shaped or J-shaped curve, where low doses of stressors trigger beneficial responses while high doses lead to toxicity. Understand how this nonlinear relationship challenges traditional toxicological paradigms.
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Small Doses, Big Impact: Hormetic Responses Unveiled

Delve into real-world examples of hormetic responses, from the beneficial effects of low-dose radiation to the adaptive mechanisms activated by moderate exercise. Learn how these responses stimulate resilience, adaptation, and overall well-being.

Hormesis in Toxicology: Redefining Risk Assessment

Unravel the complexities of hormesis in toxicology, where the concept challenges established risk assessment practices. Discover how hormesis introduces a nuanced understanding of dose-dependent effects, prompting a reevaluation of regulatory frameworks. ​

Hormesis and Adaptive Learning: "What Doesn't Kill You Makes You Stronger"

Connect the dots between hormesis and the age-old adage, "What doesn't kill you makes you stronger." Explore how the hormetic principle aligns with the idea that controlled exposure to stressors can lead to adaptive learning, fostering strength and resilience.
Learn more about Hormesis

Balancing Act: The Importance of Moderation

Emphasize the crucial role of balance and moderation in hormesis. Uncover the delicate equilibrium required for stressors to act as catalysts for positive adaptation without tipping into harmful territory.

From Sirtuins to Telomeres: Hormesis at the Cellular Level

Journey into the cellular realm and discover how hormesis influences sirtuins, telomeres, and other cellular processes. Explore the implications for cellular repair, mitochondrial function, and the potential impact on longevity.
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Practical Insights: Applying Hormesis in Everyday Life

Gain practical insights into how hormesis can be applied in daily life. Explore lifestyle choices, dietary considerations, and stress management techniques that harness the power of hormetic responses for enhanced well-being.
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​Embark on a journey of discovery as we unravel the layers of hormesis, revealing its impact on biology, health, and our quest for a balanced and resilient life. Embrace the science behind stress and strength, and learn how hormesis invites us to rethink our approach to well-being.

Learn more about Hormesis
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Magnesium Deficiency

6/13/2023

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Magnesium deficiency is often misdiagnosed because it does not show up in blood tests - only 1% of the body's magnesium is stored in the blood

99% of magnesium is stored inside of cells, of that, 95% is stored in mitochondria. So if your blood magnesium levels are low, your incredibly deficient in magnesium.
Most doctors and laboratories don't even include magnesium status in routine blood tests. Thus, most doctors don't know when their patients are deficient in magnesium, even though studies show that 80% of Americans are deficient in magnesium.

Magnesium is essential for hundreds (300-600) of metabolic function, including but not limited to:
  • Energy production
  • Vitamin D synthesis (every step)
  • Optimizing your stress response
  • Muscle relaxation
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Consider Dr. Norman Shealy's statements, "Every known illness is associated with a magnesium deficiency" and that, "magnesium is the most critical mineral required for electrical stability of every cell in the body. A magnesium deficiency may be responsible for more diseases than any other nutrient." The truth he states exposes a gapping hole in modern medicine that explains a good deal about iatrogenic death (death caused by "medicine") and disease. Because magnesium deficiency is largely overlooked, millions of Americans suffer needlessly or are having their symptoms treated with expensive drugs when they could be cured with magnesium supplementation.

One has to recognize the signs of magnesium thirst or hunger on their own since allopathic medicine is lost in this regard. It is really something much more subtle then hunger or thirst but it is comparable. In a world though where doctors and patients alike do not even pay attention to thirst and important issues of hydration, it is not hopeful that we will find many recognizing and paying attention to magnesium thirst and hunger, which is a dramatic way of expressing the concept of magnesium deficiency.

Few people are aware of the enormous role magnesium plays in our bodies. Magnesium is by far the most important mineral in the body. After oxygen, water, and basic food, magnesium may be the most important element needed by our bodies; vitally important, yet hardly known. It is more important than calcium, potassium or sodium and regulates all three of them. Millions suffer daily from magnesium deficiency without even knowing it.

In fact, there happens to be a relationship between what we perceive as thirst and deficiencies in electrolytes. I remember a person asking, "Why am I dehydrated and thirsty when I drink so much water?" Thirst can mean not only lack of water but it can also mean that one is not getting enough nutrients and electrolytes. Magnesium, Potassium, Bicarbonate, Chloride and Sodium are some principle examples and that is one of the reasons magnesium chloride is so useful.

You know all those years, when doctors used to tell their patients 'its all in your heads,' were years the medical profession was showing its ignorance. It is a torment to be magnesium deficient on one level or another. Even if it's for the enthusiastic sport person whose athletic performance is down, magnesium deficiency will disturb sleep and background stress levels and a host of other things that reflect on the quality of life. Doctors have not been using the appropriate test for magnesium - their serum blood tests just distort their perceptions. Magnesium has been off their radar screens through the decades that magnesium deficiencies have snowballed.
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Symptoms of Magnesium Deficiency

The first symptoms of deficiency can be subtle - as most magnesium is stored in the tissues, leg cramps, foot pain, or muscle 'twitches' can be the first sign. Other early signs of deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As magnesium deficiency worsens, numbness, tingling, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur.

A full outline of magnesium deficiency was beautifully presented in a recent article by Dr. Sidney Baker. "Magnesium deficiency can affect virtually every organ system of the body. With regard to skeletal muscle, one may experience twitches, cramps, muscle tension, muscle soreness, including back aches, neck pain, tension headaches and jaw joint (or TMJ) dysfunction. Also, one may experience chest tightness or a peculiar sensation that he can't take a deep breath. Sometimes a person may sigh a lot."

"Symptoms involving impaired contraction of smooth muscles include constipation; urinary spasms; menstrual cramps; difficulty swallowing or a lump in the throat-especially provoked by eating sugar; photophobia, especially difficulty adjusting to oncoming bright headlights in the absence of eye disease; and loud noise sensitivity from stapedius muscle tension in the ear."

"Other symptoms and signs of magnesium deficiency and discuss laboratory testing for this common condition. Continuing with the symptoms of magnesium deficiency, the central nervous system is markedly affected. Symptoms include insomnia, anxiety, hyperactivity and restlessness with constant movement, panic attacks, agoraphobia, and premenstrual irritability. Magnesium deficiency symptoms involving the peripheral nervous system include numbness, tingling, and other abnormal sensations, such as zips, zaps and vibratory sensations."

"Symptoms or signs of the cardiovascular system include palpitations, heart arrhythmias, and angina due to spasms of the coronary arteries, high blood pressure and mitral valve prolapse. Be aware that not all of the symptoms need to be present to presume magnesium deficiency; but, many of them often occur together. For example, people with mitral valve prolapse frequently have palpitations, anxiety, panic attacks and premenstrual symptoms. People with magnesium deficiency often seem to be "uptight." Other general symptoms include a salt craving, both carbohydrate craving and carbohydrate intolerance, especially of chocolate, and breast tenderness."
​

Magnesium is needed by every cell in the body including those of the brain. It is one of the most important minerals when considering supplementation because of its vital role in hundreds of enzyme systems and functions related to reactions in cell metabolism, as well as being essential for the synthesis of proteins, for the utilization of fats and carbohydrates. Magnesium is needed not only for the production of specific detoxification enzymes but is also important for energy production related to cell detoxification. A magnesium deficiency can affect virtually every system of the body.

One of the principle reason doctors write millions of prescriptions for tranquilizers each year is the nervousness, irritability, and jitters largely brought on by inadequate diets lacking magnesium. Persons only slightly deficient in magnesium become irritable, highly-strung, and sensitive to noise, hyper-excitable, apprehensive and belligerent. If the deficiency is more severe or prolonged, they may develop twitching, tremors, irregular pulse, insomnia, muscle weakness, jerkiness and leg and foot cramps.

If magnesium is severely deficient, the brain is particularly affected. Clouded thinking, confusion, disorientation, marked depression and even the terrifying hallucinations of delirium tremens are largely brought on by a lack of this nutrient and remedied when magnesium is given. Because large amounts of calcium are lost in the urine when magnesium is under supplied, the lack of this nutrient indirectly becomes responsible for much rampant tooth decay, poor bone development, osteoporosis and slow healing of broken bones and fractures. With vitamin B6 (pyridoxine), magnesium helps to reduce and dissolve calcium phosphate kidney stones.
​

Magnesium deficiency may be a common factor associated with insulin resistance. Symptoms of MS that are also symptoms of magnesium deficiency include muscle spasms, weakness, twitching, muscle atrophy,  an inability to control the bladder, nystagmus (rapid eye movements), hearing loss, and osteoporosis.  People with MS have higher rates of epilepsy than controls.  Epilepsy has also been linked to magnesium deficiencies.[1]
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Gastrointestinal UPSET with Magnesium

Some individuals report gastrointestinal upset with magnesium, likely due to the citrate (helpful for endothelial and metabolic function), which typically has a high bioavailability.

The nature of magnesium salts is the resulting osmotic effect - the potential laxative effect is due to magnesium (salts) remaining in the intestines causing water to be drawn toward the salts for equilibrium, leading to gastrointestinal distress. 
While it is often recommended to take magnesium with food, some potential methods to offset the laxative effect would be to consume it fasted, augmenting absorption, and/or improve hydration by consuming more water, ideally prepared by reverse osmosis. 

Another way you can avoid that laxative effect is stop the consumption of magnesium citrate and taking molecular hydrogen, which contains pure ionic metallic magnesium. 
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early warning symptoms suggestive of magnesium insufficiency

  • Physical and mental fatigue
  • Persistent under-eye twitch
  • Tension in the upper back, shoulders and neck
  • Headaches
  • Pre-menstrual fluid retention and/or breast tenderness

Possible manifestations of magnesium deficiency include

  • Low energy
  • Fatigue
  • Weakness
  • Confusion
  • Nervousness
  • Anxiousness
  • Irritability
  • Seizures (and tantrums)
  • Poor digestion
  • PMS and hormonal imbalances
  • Inability to sleep
  • Muscle tension, spasm and cramps
  • Calcification of organs
  • Weakening of the bones
  • Abnormal heart rhythm
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Severe magnesium deficiency can result in low levels of calcium in the blood (hypocalcemia). Magnesium deficiency is also associated with low levels of potassium in the blood (hypokalemia). Magnesium levels drop at night, leading to poor REM (Rapid Eye Movement) sleep cycles and unrefreshed sleep. Headaches, blurred vision, mouth ulcers, fatigue and anxiety are also early signs of depletion.

​
We hear all the time about how heart disease is the number one health crisis in the country, about how high blood pressure is the "silent killer", and about how ever increasing numbers of our citizens are having their lives and the lives of their families destroyed by diabetes, Alzheimer's disease, and a host of other chronic diseases.

Signs of severe magnesium deficiency include

  • Extreme thirst 
  • Extreme hunger 
  • Frequent urination 
  • Sores or bruises that heal slowly
  • Dry, itchy skin
  • Unexplained weight loss
  • Blurry vision that changes from day to day
  • Unusual tiredness or drowsiness
  • Tingling or numbness in the hands or feet
  • Frequent or recurring skin, gum, bladder or vaginal yeast infections
But wait a minute, aren't those the same symptoms for diabetes? Many people have diabetes for about 5 years before they show strong symptoms. By that time, some people already have eye, kidney, gum or nerve damage caused by the deteriorating condition of their cells due to insulin resistance and magnesium deficiency. Dump some mercury and arsenic on the mixture of etiologies and pronto we have the disease condition we call diabetes.
​

Magnesium deficiency is synonymous with diabetes and is at the root of many if not all cardiovascular problems.

Magnesium deficiency is a predictor of diabetes and heart disease both; diabetics both need more magnesium and lose more magnesium than most people. In two new studies, in both men and women, those who consumed the most magnesium in their diet were least likely to develop type 2 diabetes, according to a report in the January 2006 issue of the journal Diabetes Care. Until now, very few large studies have directly examined the long-term effects of dietary magnesium on diabetes. Dr. Simin Liu of the Harvard Medical School and School of Public Health in Boston says, "Our studies provided some direct evidence that greater intake of dietary magnesium may have a long-term protective effect on lowering risk," said Liu, who was involved in both studies.

The thirst of diabetes is part of the body's response to excessive urination. The excessive urination is the body's attempt to get rid of the extra glucose in the blood. This excessive urination causes the increased thirst. But we have to look at what is causing this level of disharmony. We have to probe deeper into layers of cause. The body needs to dump glucose because of increasing insulin resistance and that resistance is being fueled directly by magnesium deficiency, which makes toxic insults more damaging to the tissues at the same time.
​

When diabetics get too high blood sugars, the body creates "ketones" as a by-product of breaking down fats. These ketones cause blood acidity which causes "acidosis" of the blood, leading to Diabetic Ketoacidosis (DKA), This is a very dangerous condition that can lead to coma and death. It is also called "diabetic acidosis", "ketosis", "ketoacidosis" or "diabetic coma". DKA is a common way for new Type 1 diabetics to be diagnosed. If they fail to seek medical advice on symptoms like urination, which is driving thirst they can die of DKA.

Oral magnesium supplements reduce erythrocyte[2] dehydration.[3] In general, optimal balances of electrolytes are necessary to maintain the best possible hydration. Diabetic thirst is initiated specifically by magnesium deficiency with relative calcium excess in the cells. Even water, our most basic nutrient starts having a hard time getting into the cells with more going out through the kidneys.
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If your magnesium supplementation is not working as desired, it may be due to a lack of available ATP. It would be advised to take a bioavailable form of niacinamide to facilitate NAD+ production, approximately 30 minutes before taking the magnesium supplement. A great bioavailable source of B-vitamins, including niacinamide, is local bee pollen. 

Autism and Magnesium Deficiency

When dealing with ASD and other neurological disorders in children it is important to know the signs of low magnesium: restless, can't keep still, body rocking, grinding teeth, hiccups, noise sensitive, poor attention span, poor concentration, irritable, aggressive, ready to explode, easily stressed. When it comes to children today we need to assume a large magnesium deficiency for several reasons.
1) The foods they are eating are stripped of magnesium because foods in general, as we shall see below are declining in mineral content in an alarming way.
2) The foods many children eat are highly processed junk foods that do not provide real nutrition to the body.
3) Because most children on the spectrum are not absorbing the minerals they need even when present in the gut. Magnesium absorption is dependent on intestinal health, which is compromised totally in leaky gut syndromes and other intestinal problems that the majority of autism syndrome disorders.
4) Because the oral supplements doctors rely on are not easily absorbed, because they are not in the right form and because magnesium in general is not administered easily orally.
Modern medicine is supposed to help people not hurt them, but with their almost total ignorance of magnesium doctors end up hurting more than they help for many of the medical interventions drive down magnesium levels when they should be driving them up. Many if not most pharmaceutical drugs drive magnesium levels into very dangerous zones and surgery done without increasing magnesium levels is much more dangerous then surgery done with.
The foundation of medical arrogance is actually medical ignorance and the only reason ignorance and arrogance rule the playing field of medicine is a greed lust for power and money. Human nature seems to be at its worst in modern medicine when it should be at its best. It is sad that people have to suffer needlessly and extraordinarily tragic that allopathic medicine has turned its back on the Hippocratic Oath and all that it means.

Resources

[1] https://www.nhfw.info/magnesium.html
[2] Red blood cells are also known as RBCs, red blood corpuscles (an archaic term), haematids or erythrocytes (from Greek erythros for "red" and kytos for "hollow", with cyte translated as "cell" in modern usage). The capitalized term Red Blood Cells is the proper name in the US for erythrocytes in storage solution used in transfusion medicine.
[3] J. Clin. Invest. 100(7): 1847-1852 (1997). doi:10.1172/JCI119713. The American Society for Clinical Investigation
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Dr. DiNicolantonio: The Salt Fix

10/19/2018

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A leading cardiovascular research scientist upends the low-salt myth, proving that salt may be one solution to—rather than a cause of—our nation’s chronic disease crises.

Sure to change the national conversation about this historically treasured substance, The Salt Fix elegantly and accessibly weaves the research into a fascinating new understanding of salt’s essential role in your health and what happens when you aren’t getting enough—with far-reaching, even heart-stopping, implications.

We’ve all heard the recommendation: eat no more than a teaspoon of salt a day for a healthy heart. But there’s one big problem with this: the vast majority of us don’t need to eat low-salt diets. In fact, for most of us, more salt would be better for our health, rather than less. (Not to mention, much tastier.) Scientific research suggests that the optimal range for sodium intake is 3 to 6 grams per day (about 1 ⅓ - 2 ⅔ teaspoons of salt) for healthy adults. Now, Dr. James DiNicolantonio reveals the incredible, often baffling story of how salt became unfairly demonized—a never-before-told, century-spanning drama of competing egos and interests. Not only have we gotten it wrong, we’ve gotten it exactly backwards: eating more salt can help protect you from a host of ailments, including internal starvation, insulin resistance, diabetes, and even heart disease. (The real culprit? Another white crystal—sugar.)

Dr. DiNicolantonio in The Salt Fix shows how eating the right amount of this essential mineral will help you beat sugar cravings, achieve weight loss, improve athletic performance, increase fertility, and thrive with a healthy heart.

James J. DiNicolantonio, Pharm. D., is a respected cardiovascular research scientist, doctor of pharmacy at Saint Luke's Mid America Heart Institute in Kansas City, Missouri, and the associate editor of British Medical Journal's (BMJ) Open Heart. He is the author or coauthor of approximately 200 publications in medical literature. His research has been featured in The New York Times, ABC’s Good Morning America, TIME, Fox News, U.S. News and World Report, Yahoo! Health, BBC News, Daily Mail, Forbes, National Public Radio, and Men’s Health, among others.

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