Groups of cells, collectively known as tumor microenvironment of metastasis (TMEM), can serve as gateways for tumor cells entering the blood vessels. The researchers observed that several types of chemotherapy can increase the amounts of TMEM complexes and circulating tumor cells in the bloodstream (Karagiannis et al., 2017).
Dr. Karagiannis, the lead author of the study, found the number of doorways was increased in 20 patients receiving two common chemotherapy drugs. It should be noted such a small sample size constitutes a major limitation of this study, the results and implications of this research are very significant.
While prevention is by far the best cure for chronic disease, not everyone has this luxury. A number of modifiable risk factors are responsible for many premature or preventable diseases and deaths. Modifiable risk factors fall into three main groups (Danaei et al., 2011):
In regards to dietary interventions, numerous studies have substantiated the chemopreventative effect of increasing cruciferous vegetable intake against cancer. As a chemoprevention agent, sulforaphane, the active molecule in cruciferous vegetables, possesses many advantages, such as high bioavailability and low toxicity (Li et al., 2010).
Increasing the consumption of cruciferous vegetables is only one of the many preventive measures that can be taken when taking control of your health. Remember, the health of your environment reflects the health of your body; you are the product of your environment.
Karagiannis, G., Pastoriza, J., Wang, Y., Harney, A., Entenberg, D., & Pignatelli, J. et al. (2017). Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. Cancer, 9(397). http://dx.doi.org/10.1126/scitranslmed.aan0026
Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H., & Newman, B. et al. (2010). Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells. Clinical Cancer Research, 16(9), 2580-2590. http://dx.doi.org/10.1158/1078-0432.ccr-09-2937
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